Antibiotics susceptibility patterns of uropathogenic E. coli with special reference to fluoroquinolones in different age and gender groups

To identify frequency of uropathogenic Escherichia coli and its antibiotic susceptibility pattern. This cross-sectional study was conducted at Khyber Teaching Hospital, Peshawar, Pakistan, from January 2014 to September 2015, and comprised urine specimens. Biochemical techniques were used to identif...

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Bibliographic Details
Published in:Journal of the Pakistan Medical Association 2017-08, Vol.67 (8), p.1161-1165
Main Authors: Ali, Imran, Shabbir, Muhammad
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Amikacin - pharmacology
Analysis
Anti-Bacterial Agents - pharmacology
Antibiotics
Cefoperazone - pharmacology
Child
Child, Preschool
Cross-Sectional Studies
Drug Resistance, Bacterial
Escherichia coli - drug effects
Escherichia coli Infections - microbiology
Female
Fluoroquinolones - pharmacology
Humans
Imipenem - pharmacology
Infant
Male
Meropenem - pharmacology
Microbial Sensitivity Tests
Middle Aged
Sulbactam - pharmacology
Tazobactam - pharmacology
Urinary Tract Infections - microbiology
Young Adult
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Summary:To identify frequency of uropathogenic Escherichia coli and its antibiotic susceptibility pattern. This cross-sectional study was conducted at Khyber Teaching Hospital, Peshawar, Pakistan, from January 2014 to September 2015, and comprised urine specimens. Biochemical techniques were used to identify Escherichia coli and antibiotic susceptibility was determined by Kirby-Bauer disk diffusion and minimum inhibitory concentration methods. SPSS 23 was used for data analysis. Of the 787 urine samples, 458(58.2%) grew significant positive growths. Escherichia coli growths were present in 351(76.6%) positive cultures of which 108(30.8%) came from males and 243(69.2%) from female patients. Resistance to fluoroquinolones tested was almost similar (p>0.05). Escherichia coli was highly sensitive to imipenem (98.6%), meropenem (97.8%), tazobactum (96.2%), cefoperazone+sulbactam (93.9%) and amikacin(92.5%). Escherichia coli was a common pathogen causing urinary tract infections and was highly sensitive to imipenem, meropenem, tazobactum, cefoperazone+sulbactam and amikacin.
ISSN:0030-9982