Lack of genotoxic effect in workers exposed to very low doses of 1,3-butadiene

1,3-Butadiene (BD), a probable carcinogen to humans, has been shown to have an ill-defined genotoxicity in occupationally exposed workers. In the present study, the influence of exposure to very low doses of BD and to cigarette smoking was investigated on some cytogenetic endpoints, namely, sister c...

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Bibliographic Details
Published in:Archives of toxicology 2006-06, Vol.80 (6), p.378-381
Main Authors: LOVREGLIO, Piero, BUKVIC, Nenad, FUSTINONI, Silvia, BALLINI, Andrea, DRAGO, Ignazio, FOA, Vito, GUANTI, Ginevra, SOLEO, Leonardo
Format: Article
Language:English
Subjects:
Adult
Air Pollutants - adverse effects
Biological and medical sciences
Biomarkers
Butadienes - adverse effects
Cell Proliferation - drug effects
Chromosome Aberrations
Dose-Response Relationship, Drug
Humans
Leukocytes, Mononuclear - drug effects
Leukocytes, Mononuclear - pathology
Male
Medical sciences
Mutagens - adverse effects
Occupational Exposure
Regression analysis
Sister Chromatid Exchange - drug effects
Smoking - adverse effects
Studies
Toxicology
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Summary:1,3-Butadiene (BD), a probable carcinogen to humans, has been shown to have an ill-defined genotoxicity in occupationally exposed workers. In the present study, the influence of exposure to very low doses of BD and to cigarette smoking was investigated on some cytogenetic endpoints, namely, sister chromatid exchanges (SCE), chromosomal aberrations (CA) and cells with a high frequency of SCE (HFC), in peripheral blood lymphocytes. Twenty-seven male workers employed in a petrochemical plant and 26 matched controls were included in the study. As regards the airborne BD values, there was a significant difference between exposed (median BD value 1.5, min-max 0.2-69.0 microg/m3) and non-exposed workers (median BD value 0.4, min-max
ISSN:0340-5761
1432-0738
DOI:10.1007/s00204-005-0046-0