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The identification of pyrazolo[1,5- a]pyridines as potent p38 kinase inhibitors
A series of pyrazolo[1,5- a]pyridine derivatives was designed and synthesized as novel potent p38 kinase inhibitors. Our approaches towards improving in vitro metabolism and in vivo pharmacokinetic properties of the series are described. A series of pyrazolo[1,5- a]pyridine derivatives was designed...
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| Published in: | Bioorganic & medicinal chemistry 2008-10, Vol.18 (20), p.5428-5430 |
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| Main Authors: | , , , , , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c415t-2f93a857e961c8a2bc62fcf0b34c81ca0b738abe5f282c4eecf8ed518301742b3 |
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| cites | cdi_FETCH-LOGICAL-c415t-2f93a857e961c8a2bc62fcf0b34c81ca0b738abe5f282c4eecf8ed518301742b3 |
| container_end_page | 5430 |
| container_issue | 20 |
| container_start_page | 5428 |
| container_title | Bioorganic & medicinal chemistry |
| container_volume | 18 |
| creator | Cheung, Mui Harris, Philip A. Badiang, Jennifer G. Peckham, Gregory E. Chamberlain, Stanley D. Alberti, Michael J. Jung, David K. Harris, Stephanie S. Bramson, Neal H. Epperly, Andrea H. Stimpson, Stephen A. Peel, Michael R. |
| description | A series of pyrazolo[1,5-
a]pyridine derivatives was designed and synthesized as novel potent p38 kinase inhibitors. Our approaches towards improving in vitro metabolism and in vivo pharmacokinetic properties of the series are described.
A series of pyrazolo[1,5-
a]pyridine derivatives was designed and synthesized as novel potent p38 kinase inhibitors. Our approaches towards improving in vitro metabolism and in vivo pharmacokinetic properties of the series are described. |
| doi_str_mv | 10.1016/j.bmcl.2008.09.040 |
| format | article |
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a]pyridine derivatives was designed and synthesized as novel potent p38 kinase inhibitors. Our approaches towards improving in vitro metabolism and in vivo pharmacokinetic properties of the series are described.
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a]pyridine derivatives was designed and synthesized as novel potent p38 kinase inhibitors. Our approaches towards improving in vitro metabolism and in vivo pharmacokinetic properties of the series are described.
A series of pyrazolo[1,5-
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Antiinflammatory agents</subject><subject>Chemistry, Pharmaceutical - methods</subject><subject>Dogs</subject><subject>Drug Design</subject><subject>Enzyme Inhibitors - chemical synthesis</subject><subject>Enzyme Inhibitors - pharmacokinetics</subject><subject>Humans</subject><subject>Inhibitory Concentration 50</subject><subject>Leukocytes, Mononuclear - drug effects</subject><subject>MAP Kinase Signaling System</subject><subject>Medical sciences</subject><subject>p38 Inhibitor</subject><subject>p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors</subject><subject>p38 Mitogen-Activated Protein Kinases - metabolism</subject><subject>Pharmacology. 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Antiinflammatory agents</topic><topic>Chemistry, Pharmaceutical - methods</topic><topic>Dogs</topic><topic>Drug Design</topic><topic>Enzyme Inhibitors - chemical synthesis</topic><topic>Enzyme Inhibitors - pharmacokinetics</topic><topic>Humans</topic><topic>Inhibitory Concentration 50</topic><topic>Leukocytes, Mononuclear - drug effects</topic><topic>MAP Kinase Signaling System</topic><topic>Medical sciences</topic><topic>p38 Inhibitor</topic><topic>p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors</topic><topic>p38 Mitogen-Activated Protein Kinases - metabolism</topic><topic>Pharmacology. Drug treatments</topic><topic>Pyrazolopyridine</topic><topic>Pyridines - chemical synthesis</topic><topic>Pyridines - pharmacokinetics</topic><topic>Rats</topic><topic>Structure-Activity Relationship</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheung, Mui</creatorcontrib><creatorcontrib>Harris, Philip A.</creatorcontrib><creatorcontrib>Badiang, Jennifer G.</creatorcontrib><creatorcontrib>Peckham, Gregory E.</creatorcontrib><creatorcontrib>Chamberlain, Stanley D.</creatorcontrib><creatorcontrib>Alberti, Michael J.</creatorcontrib><creatorcontrib>Jung, David K.</creatorcontrib><creatorcontrib>Harris, Stephanie S.</creatorcontrib><creatorcontrib>Bramson, Neal H.</creatorcontrib><creatorcontrib>Epperly, Andrea H.</creatorcontrib><creatorcontrib>Stimpson, Stephen A.</creatorcontrib><creatorcontrib>Peel, Michael R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Bioorganic & medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheung, Mui</au><au>Harris, Philip A.</au><au>Badiang, Jennifer G.</au><au>Peckham, Gregory E.</au><au>Chamberlain, Stanley D.</au><au>Alberti, Michael J.</au><au>Jung, David K.</au><au>Harris, Stephanie S.</au><au>Bramson, Neal H.</au><au>Epperly, Andrea H.</au><au>Stimpson, Stephen A.</au><au>Peel, Michael R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The identification of pyrazolo[1,5- a]pyridines as potent p38 kinase inhibitors</atitle><jtitle>Bioorganic & medicinal chemistry</jtitle><addtitle>Bioorg Med Chem Lett</addtitle><date>2008-10-15</date><risdate>2008</risdate><volume>18</volume><issue>20</issue><spage>5428</spage><epage>5430</epage><pages>5428-5430</pages><issn>0960-894X</issn><issn>0968-0896</issn><eissn>1464-3405</eissn><eissn>1464-3391</eissn><abstract>A series of pyrazolo[1,5-
a]pyridine derivatives was designed and synthesized as novel potent p38 kinase inhibitors. Our approaches towards improving in vitro metabolism and in vivo pharmacokinetic properties of the series are described.
A series of pyrazolo[1,5-
a]pyridine derivatives was designed and synthesized as novel potent p38 kinase inhibitors. Our approaches towards improving in vitro metabolism and in vivo pharmacokinetic properties of the series are described.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>18818075</pmid><doi>10.1016/j.bmcl.2008.09.040</doi><tpages>3</tpages></addata></record> |
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| source | ScienceDirect Journals |
| subjects | Animals Anti-Inflammatory Agents - chemical synthesis Anti-Inflammatory Agents - pharmacology Area Under Curve Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Chemistry, Pharmaceutical - methods Dogs Drug Design Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - pharmacokinetics Humans Inhibitory Concentration 50 Leukocytes, Mononuclear - drug effects MAP Kinase Signaling System Medical sciences p38 Inhibitor p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors p38 Mitogen-Activated Protein Kinases - metabolism Pharmacology. Drug treatments Pyrazolopyridine Pyridines - chemical synthesis Pyridines - pharmacokinetics Rats Structure-Activity Relationship |
| title | The identification of pyrazolo[1,5- a]pyridines as potent p38 kinase inhibitors |
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