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Adipose tissue inflammation in obesity: a metabolic or immune response?

•Immunometabolism of the adipose tissue affects insulin resistance and obesity.•Type 2 immune response protects against diet-induced obesity.•Cytokines modulate adipocyte metabolism. Adipose tissue is not only a reservoir for energy, but also an immune organ. In the context of obesity, the developme...

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Bibliographic Details
Published in:Current opinion in pharmacology 2017-12, Vol.37, p.35-40
Main Author: Stolarczyk, Emilie
Format: Article
Language:English
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Summary:•Immunometabolism of the adipose tissue affects insulin resistance and obesity.•Type 2 immune response protects against diet-induced obesity.•Cytokines modulate adipocyte metabolism. Adipose tissue is not only a reservoir for energy, but also an immune organ. In the context of obesity, the development of insulin resistance is now recognised to be initiated by inflammation of the adipose tissue. However, the primary events triggering this inflammation are still unclear, as a complex combination of endocrine and immune factors act to regulate this adipose tissue microenvironment. Below we discuss the different factors involved and how they affect the biology of the adipose tissue in obesity.
ISSN:1471-4892
1471-4973
DOI:10.1016/j.coph.2017.08.006