The role of TGF-beta signaling in dendritic cell tolerance

Transforming growth factor beta (TGF-β) is a pleiotropic cytokine present in vertebrate and invertebrate organisms that functions in numerous physiological and pathological processes. TGF-β impacts all the cells of the immune system, and of the three known TGF-β isoforms, TGF-β1 is the predominant i...

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Bibliographic Details
Published in:Immunologic research 2017-10, Vol.65 (5), p.987-994
Main Authors: Esebanmen, Grace E., Langridge, William H. R.
Format: Article
Language:English
Subjects:
Adaptive systems
Allergology
Animals
Biomedical and Life Sciences
Biomedicine
Cell Differentiation
Dendritic cells
Dendritic Cells - immunology
Humans
Immune system
Immune Tolerance
Immunity
Immunological tolerance
Immunology
Internal Medicine
Isoforms
Lymphocytes T
Medicine/Public Health
Protein Isoforms - immunology
Review
Signal Transduction
T-Lymphocytes, Regulatory - immunology
Transforming Growth Factor beta - immunology
Transforming growth factor-b
Transforming growth factor-b1
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Summary:Transforming growth factor beta (TGF-β) is a pleiotropic cytokine present in vertebrate and invertebrate organisms that functions in numerous physiological and pathological processes. TGF-β impacts all the cells of the immune system, and of the three known TGF-β isoforms, TGF-β1 is the predominant isoform expressed in immune cells. TGF-β1 is known to play a pivotal role in the function of all immune cells especially in the regulation of T cell development and in the induction of immunological tolerance in dendritic cells (DCs). Based on the importance of DCs in regulation of the innate and adaptive arms of the immune system, in this review we explore the regulatory functions of TGF-β required for establishment and maintenance of DC-mediated immune tolerance.
ISSN:0257-277X
1559-0755
DOI:10.1007/s12026-017-8944-9