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Nocturnal motor activity and light exposure: Objective actigraphy-based marks of melancholic and non-melancholic depressive disorder. Brief report

Differentiation of melancholic (MEL) and non-melancholic (N-MEL) depression results from subjective assessment of psychomotor disturbance, which obscures their accurate diagnosis. CORE instrument assigned participants with severe or refractory depression to MEL or N-MEL group. Participants underwent...

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Bibliographic Details
Published in:Psychiatry research 2017-12, Vol.258, p.587-590
Main Authors: Tonon, André Comiran, Fuchs, Daniel Fernando Paludo, Barbosa Gomes, William, Levandovski, Rosa, Pio de Almeida Fleck, Marcelo, Hidalgo, Maria Paz Loayza, da Silva Alencastro, Luciano
Format: Article
Language:English
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Summary:Differentiation of melancholic (MEL) and non-melancholic (N-MEL) depression results from subjective assessment of psychomotor disturbance, which obscures their accurate diagnosis. CORE instrument assigned participants with severe or refractory depression to MEL or N-MEL group. Participants underwent 7 days of actigraphy. Data was fitted to a cosinusoidal curve corresponding to a 24-h rhythm. Nocturnal activity was significantly higher in N-MEL. ROC curve shows that average night activity discriminate participants with 71% sensitivity and 100% specificity (area under the curve = 0.84). Actigraphy contribute to the objective differentiation of depression subtypes, and have implications for research on their neurobiology and clinical management. [Display omitted] •Nocturnal activity differentiates melancholic from non-melancholic depression.•Patterns of activity differ between groups, regardless of the severity of symptoms.•Actigraphy can objectively assess melancholic features.
ISSN:0165-1781
1872-7123
DOI:10.1016/j.psychres.2017.08.025