Phoenixin-14 injected intracerebroventricularly but not intraperitoneally stimulates food intake in rats

•Phoenixin-14 increases light phase food intake after intracerebroventricular injection.•Phoenixin-14 does not modulate food intake when injected icv during the dark phase.•Phoenixin-14 does not modulate food intake when injected intraperitoneally.•Phoenixin-14 might be involved in the central stimu...

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Bibliographic Details
Published in:Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2017-10, Vol.96, p.53-60
Main Authors: Schalla, Martha, Prinz, Philip, Friedrich, Tiemo, Scharner, Sophie, Kobelt, Peter, Goebel-Stengel, Miriam, Rose, Matthias, Stengel, Andreas
Format: Article
Language:English
Subjects:
Animals
Behavior
Brain-gut-axis
Central Nervous System Stimulants
Eating - drug effects
Feeding Behavior - drug effects
Food intake microstructure
Injections, Intraperitoneal
Injections, Intraventricular
Male
Orexigenic
Peptides - administration & dosage
Peptides - pharmacology
Rats
Rats, Sprague-Dawley
Water intake
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Summary:•Phoenixin-14 increases light phase food intake after intracerebroventricular injection.•Phoenixin-14 does not modulate food intake when injected icv during the dark phase.•Phoenixin-14 does not modulate food intake when injected intraperitoneally.•Phoenixin-14 might be involved in the central stimulation of food intake. Phoenixin, a recently discovered 20-amino acid peptide was implicated in reproduction. However, the expression in food intake-regulatory nuclei such as the paraventricular nucleus, the arcuate nucleus and the nucleus of the solitary tract suggests an implication of phoenixin in food intake regulation. Therefore, we investigated the effects of phoenixin-14, the shorter form of phoenixin, on food intake following intracerebroventricular (icv) and intraperitoneal (ip) injection in ad libitum fed male Sprague-Dawley rats. Phoenixin-14 injected icv (0.2, 1.7 or 15nmol/rat) during the light phase induced a dose-dependent increase of light phase food intake reaching significance at a minimum dose of 1.7 nmol/rat (+72%, p0.05). The increase of food intake following icv phoenixin-14 was not associated with a significant alteration of grooming behavior (0.4-fold, p=0.377) or locomotion (6-fold, p=0.066) compared to vehicle. When injected ip at higher doses (0.6, 5nmol/kg or 45nmol/kg body weight) during the light phase, phoenixin-14 did not affect food intake (p>0.05). In summary, phoenixin-14 exerts a centrally-mediated orexigenic effect.
ISSN:0196-9781
1873-5169
DOI:10.1016/j.peptides.2017.08.004