Norway spruce galactoglucomannans exhibiting immunomodulating and radical-scavenging activities

Wood-derived naturally acetylated galactoglucomannans (AcGGM) can be recovered even in ton-scale at mechanical pulp mills using spruce as raw material. These cell wall polysaccharides have a great potential as hydrocolloids and bioactive polymers in food and pharmaceutical applications, or as starti...

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Bibliographic Details
Published in:International journal of biological macromolecules 2008, Vol.42 (1), p.1-5
Main Authors: Ebringerová, Anna, Hromádková, Zdenka, Hříbalová, Vera, Xu, Chunlin, Holmbom, Bjarne, Sundberg, Anna, Willför, Stefan
Format: Article
Language:English
Subjects:
Animals
Biphenyl Compounds - antagonists & inhibitors
Biphenyl Compounds - toxicity
Free Radical Scavengers - chemistry
Free Radical Scavengers - isolation & purification
Free Radical Scavengers - pharmacology
Hydrazines - antagonists & inhibitors
Hydrazines - toxicity
Immunologic Factors - chemistry
Immunologic Factors - isolation & purification
Immunologic Factors - pharmacology
Lymphocyte Activation
Lymphocytes - drug effects
Male
Mannans - chemistry
Mannans - isolation & purification
Mannans - pharmacology
Mitogenic and comitogenic activity
O-Acetyl-galactoglucomannan
Picea
Picea abies
Picrates
Radical-scavenging activity
Rats
Rats, Wistar
Spruce wood
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Summary:Wood-derived naturally acetylated galactoglucomannans (AcGGM) can be recovered even in ton-scale at mechanical pulp mills using spruce as raw material. These cell wall polysaccharides have a great potential as hydrocolloids and bioactive polymers in food and pharmaceutical applications, or as starting material for production of functional polymers. The immunostimulatory activity of both AcGGM and its deacetylated form (GGM) was now in vitro tested. The biological response of both AcGGM and GGM in the lymphocyte transformation test was dose-dependent. The direct mitogenic as well as comitogenic activities of the AcGGM were comparable to those of the immunogenic corn cob xylan used as control, and GGM showed significantly higher biological responses also at lower doses. In contrast to GGM, AcGGM possessed also DPPH radical-scavenging activity. The results suggested that the spruce AcGGM and GGM are potentially important as additives with immuno-potentiating and antioxidant properties in food products and pharmaceutical formulations.
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2007.08.001