Parp-1 deficiency does not increase the frequency of tumors in the oral cavity and esophagus of ICR/129Sv mice by 4-nitroquinoline 1-oxide, a carcinogen producing bulky adducts

The impact of poly(ADP-ribose) polymerase-1 ( Parp−1)-deficiency on 4-nitroquinoline 1-oxide (4NQO)-induced carcinogenesis was studied in mice with an ICR/129Sv mixed genetic background. Parp-1 +/+ , Parp−1 +/− and Parp-1 −/− animals given 4NQO for thirty-two weeks at 0.001% in their drinking water...

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Bibliographic Details
Published in:Cancer letters 2006-09, Vol.241 (1), p.87-92
Main Authors: Gunji, Akemi, Uemura, Akiko, Tsutsumi, Masahiro, Nozaki, Tadashige, Kusuoka, Osamu, Omura, Ken, Suzuki, Hiroshi, Nakagama, Hitoshi, Sugimura, Takashi, Masutani, Mitsuko
Format: Article
Language:English
Subjects:
4-Nitroquinoline 1-oxide
4-Nitroquinoline-1-oxide - toxicity
Animals
Carcinogenesis
Carcinogens - toxicity
Deoxyribonucleic acid
DNA
Drinking water
Esophageal Neoplasms - chemically induced
Esophageal Neoplasms - genetics
Esophageal Neoplasms - physiopathology
Experiments
Genetic testing
Knockout mice
Medical research
Mice
Mice, Inbred ICR
Mice, Knockout
Mouth Neoplasms - chemically induced
Mouth Neoplasms - genetics
Mouth Neoplasms - physiopathology
Poly (ADP-Ribose) Polymerase-1
Poly(ADP-ribose) Polymerases - genetics
Poly(ADP-ribose) Polymerases - physiology
Rodents
Squamous cell carcinoma
Tumors
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Summary:The impact of poly(ADP-ribose) polymerase-1 ( Parp−1)-deficiency on 4-nitroquinoline 1-oxide (4NQO)-induced carcinogenesis was studied in mice with an ICR/129Sv mixed genetic background. Parp-1 +/+ , Parp−1 +/− and Parp-1 −/− animals given 4NQO for thirty-two weeks at 0.001% in their drinking water developed papillomas and squamous cell carcinomas of the tongue, palate and esophagus, but with no statistically significant variation with the Parp−1 genotype. Thus Parp-1 deficiency does not elevate susceptibility to carcinogenesis induced by a carcinogen which gives rise to bulky DNA lesions. This study also indicated that the ICR/129Sv mixed genetic background is associated with high yield induction of esophageal tumors by 4NQO.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2005.10.003