Gene—Gene Interactions of Apolipoprotein Gene Polymorphic Variants in Adolescents with Essential Arterial Hypertension and Dyslipidemia

Using MDR bioinformatic analysis we studied gene—gene interactions between apolipoprotein genes in adolescents with essential arterial hypertension and dyslipidemia against the background of essential arterial hypertension. Optimal models of gene—gene interactions were formed. The six-locus model wa...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2017-08, Vol.163 (4), p.456-460
Main Authors: Kalyuzhnaya, O. V., Bairova, T. A., Kolesnikova, L. I.
Format: Article
Language:English
Subjects:
Adolescent
Alleles
Anopheles
Apolipoprotein A-I - genetics
Apolipoproteins
Apolipoproteins B - genetics
Apolipoproteins E - genetics
Biomedical and Life Sciences
Biomedicine
Cell Biology
Child
Dyslipidemias - genetics
Dyslipidemias - metabolism
Female
Genes
Genetic polymorphisms
Genetics
Genotype
Humans
Hypertension
Hypertension - genetics
Hypertension - metabolism
Internal Medicine
Laboratory Medicine
Male
Pathology
Physiological aspects
Polymorphism, Genetic - genetics
Protein Binding - genetics
Protein Binding - physiology
Risk factors
Type 2 diabetes
Youth
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Summary:Using MDR bioinformatic analysis we studied gene—gene interactions between apolipoprotein genes in adolescents with essential arterial hypertension and dyslipidemia against the background of essential arterial hypertension. Optimal models of gene—gene interactions were formed. The six-locus model was the most significant: (ApoA1(+83T) , ApoA1(-75A) , ApoB(Del) , ApoC3(S2) , ApoE(ε2) , ApoE(ε4) . The maximum synergism in both adolescent groups were shown for allele variants ApoA1(-75A) , ApoB(Del) , and ApoE(ε4) . The maximum contribution to gene—gene interactions entropy was made by allelic polymorphisms ApoA1(-75A) and ApoE(ε4) and (in the comorbid pathology group) for ApoE(ε4) + ApoB(Del) .
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-017-3827-6