Elemental fingerprinting of schizophrenia patient blood plasma before and after treatment with antipsychotics

Antipsychotics are the main line of treatment for schizophrenia, a disorder that affects about 1% of the worldwide population. Considering the poor performance of antipsychotics on patients, this work aimed at detecting alterations in the elemental profile resulting from the use of this type of medi...

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Bibliographic Details
Published in:European archives of psychiatry and clinical neuroscience 2018-09, Vol.268 (6), p.565-570
Main Authors: Sussulini, Alessandra, Erbolato, Helena Munhoz, Pessôa, Gustavo de Souza, Arruda, Marco Aurélio Zezzi, Steiner, Johann, Martins-de-Souza, Daniel
Format: Article
Language:English
Subjects:
Adult
Aluminum
Antipsychotic Agents - pharmacology
Antipsychotics
Blood - drug effects
Blood Chemical Analysis
Calcium
Cohort Studies
Fingerprinting
Humans
Iron
Magnesium
Mass Spectrometry - methods
Mass spectroscopy
Medicine
Medicine & Public Health
Mental disorders
Metal ions
Neurosciences
Original Paper
Patients
Phosphorus
Psychiatry
Psychotropic drugs
Schizophrenia
Schizophrenia - blood
Schizophrenia - diet therapy
Sodium
Spectrophotometry, Atomic - methods
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Summary:Antipsychotics are the main line of treatment for schizophrenia, a disorder that affects about 1% of the worldwide population. Considering the poor performance of antipsychotics on patients, this work aimed at detecting alterations in the elemental profile resulting from the use of this type of medication using an elemental fingerprinting strategy. We evaluated 56 plasma samples from schizophrenia patients by inductively coupled plasma mass spectrometry (ICP-MS) before (t0) and after 6 weeks (t6) of treatment. The level of response of the patients (good vs. poor responders) and the medications taken were considered. Zinc, aluminum, phosphorus, and iron levels were found to be increased, whereas sodium, potassium, calcium, and magnesium levels decreased after treatment. Aluminum presented a higher level in poor responders at t0 when compared to good responders. At t6, iron showed an increased level when compared to t0 for good responders; however, its level remained constant in poor responders. The results of this exploratory study provide clues for further investigations on the role of metal ions in the treatment of schizophrenia.
ISSN:0940-1334
1433-8491
DOI:10.1007/s00406-017-0836-4