Transcranial direct current stimulation versus caffeine as a fatigue countermeasure

• Published in: Brain stimulation 2017-11, Vol.10 (6), p.1070-1078
• Main Authors: McIntire, Lindsey K., McKinley, R. Andy, Nelson, Justin M., Goodyear, Chuck
• Format: Article
• Language: English
• Subjects: Adult; Attention - drug effects; Attention - physiology; Caffeine; Caffeine - administration & dosage; Central Nervous System Stimulants - administration & dosage; Chewing Gum; Fatigue; Fatigue - physiopathology; Fatigue - psychology; Fatigue - therapy; Female; Humans; Male; Memory, Short-Term - drug effects; Memory, Short-Term - physiology; Photic Stimulation - methods; Psychomotor Performance - drug effects; Psychomotor Performance - physiology; Reaction Time - drug effects; Reaction Time - physiology; Sleep deprivation; Sleep Deprivation - physiopathology; Sleep Deprivation - psychology; Sleep Deprivation - therapy; Transcranial direct current stimulation; Transcranial Direct Current Stimulation - methods; Wakefulness - drug effects; Wakefulness - physiology
• ISSN: 1935-861X; 1876-4754
• DOI: 10.1016/j.brs.2017.08.005

To assess the efficacy of using transcranial direct current stimulation (tDCS) to remediate the deleterious effects of fatigue induced by sleep deprivation and compare these results to caffeine, a commonly used fatigue countermeasure. Based on previous research, tDCS of the dorsolateral prefrontal cortex (DLPFC) can modulate attention and arousal. The authors hypothesize that tDCS can be an effective fatigue countermeasure. Five groups of ten participants each received either active tDCS and placebo gum at 1800, caffeine gum with sham tDCS at 1800, active tDCS and placebo gum at 0400, caffeine gum with sham tDCS at 0400, or sham tDCS with placebo gum at 1800 and 0400 during 36-h of sustained wakefulness. Participants completed a vigilance task, working memory task, psychomotor vigilance task (PVT), and a procedural game beginning at 1800 h and continued every two hours throughout the night until 1900 the next day. tDCS dosed at 1800 provided 6 h of improved attentional accuracy and reaction times compared to the control group. Caffeine did not produce an effect. Both tDCS groups also had an improved effect on mood. Participants receiving tDCS reported feeling more vigor, less fatigue, and less bored throughout the night compared to the control and caffeine groups. We believe tDCS could be a powerful fatigue countermeasure. The effects appear to be comparable or possibly more beneficial than caffeine because they are longer lasting and mood remains more positive. •tDCS provided 24 h of improved arousal, while caffeine provided 12 h.•tDCS sustained attention levels for 6 h post-stimulation.•tDCS stabilized mood over the 36-h sleep deprivation vigil.•tDCS could be a powerful fatigue countermeasure.