Bracken-fern extracts can be clastogenic or aneugenic depending on the tissue cell assay

The consumption of bracken fern ( Pteridium aquilinum) as food is associated with a high incidence of cancer in humans and animals. We investigated the cytogenetic effects of bracken-fern extracts (hexane extract—HE, ethanol extract—EE, hot water extract—HWE and cold water extract—CWE) on chromosome...

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Bibliographic Details
Published in:Food and chemical toxicology 2006-11, Vol.44 (11), p.1845-1848
Main Authors: de Fátima M. Almeida Santos, Maria, Dórea, José G., Luna, Helena
Format: Article
Language:English
Subjects:
Aneuploidy
animal models
Animals
Biological and medical sciences
bone marrow cells
Bone Marrow Cells - drug effects
Bone Marrow Cells - pathology
Bracken fern
carcinogenesis
Carcinogenesis, carcinogens and anticarcinogens
carcinogens
Chemical agents
Chromosome aberrations
Chromosome Breakage
chromosome segregation
Clastogenesis
clastogenic
cytogenetic analysis
DNA damage
DNA fragmentation
ethanol
Ethanol - chemistry
Female
hexane
Hexanes - chemistry
hot water treatment
Medical genetics
Medical sciences
Mice
Mutagens - toxicity
natural toxicants
Peritoneal Cavity - cytology
peritoneum
plant extracts
Plant Extracts - toxicity
Plant poisons toxicology
plant-based foods
Pteridium - chemistry
Pteridium aquilinum
Solvents - chemistry
supercritical fluid extraction
Toxicology
Tumors
Water - chemistry
water temperature
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Summary:The consumption of bracken fern ( Pteridium aquilinum) as food is associated with a high incidence of cancer in humans and animals. We investigated the cytogenetic effects of bracken-fern extracts (hexane extract—HE, ethanol extract—EE, hot water extract—HWE and cold water extract—CWE) on chromosomes of peritoneal and bone-marrow cells of Swiss mice. In peritoneal cells, all four treatments (HE, EE, HWE and CWE) induced structural chromosome aberrations, but the EE also induced numerical chromosome aberrations. In bone-marrow cells both HE and CWE induced structural chromosome aberrations; additionally, the number of abnormal metaphases was higher in peritoneum than in bone marrow. We suggest that bracken fern induces cytogenetic damage through DNA strand breaks and affects chromosome segregation.
ISSN:0278-6915
1873-6351
DOI:10.1016/j.fct.2006.06.006