Growth differentiation factor 15 as a predictor of adverse renal outcomes in patients with immunoglobulin A nephropathy

Background Growth differentiation factor 15 (GDF 15) has recently been reported as a useful prognostic marker in patients with chronic inflammatory disease and heart disease. Aim To evaluate the role of GDF 15 as a potential prognostic predictor of renal outcome in immunoglobulin A nephropathy (IgAN...

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Published in:Internal medicine journal 2017-12, Vol.47 (12), p.1393-1399
Main Authors: Na, Ki R., Kim, Yoo H., Chung, Hyo K., Yeo, Min‐Kyung, Ham, Young R., Jeong, Jin Y., Kim, Koon S., Lee, Kang W., Choi, Dae E.
Format: Article
Language:English
Subjects:
Atrophy
Biopsy
Coronary artery disease
Enzyme-linked immunosorbent assay
Epidermal growth factor receptors
Fibrosis
GDF 15
Glomerulonephritis
Heart diseases
Hemodialysis
IgA nephropathy
Immunoglobulin A
Immunoglobulins
Kidneys
Nephropathy
renal fibrosis
renal inflammation
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Summary:Background Growth differentiation factor 15 (GDF 15) has recently been reported as a useful prognostic marker in patients with chronic inflammatory disease and heart disease. Aim To evaluate the role of GDF 15 as a potential prognostic predictor of renal outcome in immunoglobulin A nephropathy (IgAN). Methods In total, 212 patients in the Chungnam National Hospital glomerulonephritis cohort, who were diagnosed as biopsy‐proven IgAN between March 2010 and June 2014, were included. GDF Fifteen was analysed by the enzyme‐linked immunosorbent assay. Cut‐off values of the GDF 15 and the hazard ratio of it resulting in haemodialysis within 2 years were analysed. Results The level of serum GDF 15 was negatively correlated with the initial eGFR. A serum GDF 15 level of more than 496.32 pg/mL showed 90% sensitivity and 72.9% specificity to predict the possibility of it resulting in haemodialysis within 2 years. In addition, a GDF 15 level higher than 490.4 pg/mL showed 63.64% sensitivity and 65% specificity to predict a decline in eGFR > 30 mL/min within 1 year of follow up. Moreover, initial serum GDF 15 level was associated with the development of interstitial fibrosis/tubular atrophy. Conclusions Initial serum GDF 15 level showed an inverse correlation with serum eGFR and was associated with worse renal outcome. Our results suggested that GDF 15 may play a role as a potential prognosticator in IgAN.
ISSN:1444-0903
1445-5994
DOI:10.1111/imj.13614