Preparation and biocompatibility of crosslinked poly(3-hydroxyundecenoate)

A sticky polymer, poly(3-hydroxyundecenoate) (PHU), was produced by Pseudomonas oleovorans when nonanoate and undecenoate were used as carbon sources. Crosslinked PHU (CL-PHU) was prepared by heating using benzoyl peroxide as a crosslinker. According to the degree of crosslinking in the polymer, thr...

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Bibliographic Details
Published in:International journal of biological macromolecules 2018-02, Vol.107 (Pt A), p.276-282
Main Authors: Chung, Chungwook, Chung, Kyudon, Kim, Do Young, Lee, Sun Hee, Kim, Jong-Sik, Rhee, Young Ha
Format: Article
Language:English
Subjects:
Adhesive force
Animals
Benzoyl Peroxide - chemistry
Biocompatible Materials - chemistry
Biocompatible Materials - pharmacology
Calorimetry, Differential Scanning
Cell Adhesion - drug effects
Cell Proliferation - drug effects
CHO Cells
Cricetulus
Cross-Linking Reagents - chemistry
Crosslinked poly(3-hydroxyundecenoates)
Microscopy, Atomic Force
Polymers - chemistry
Polymers - pharmacology
Pseudomonas oleovorans - chemistry
Spectroscopy, Fourier Transform Infrared
Surface Properties
Surface roughness
Undecylenic Acids - chemistry
Undecylenic Acids - pharmacology
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Summary:A sticky polymer, poly(3-hydroxyundecenoate) (PHU), was produced by Pseudomonas oleovorans when nonanoate and undecenoate were used as carbon sources. Crosslinked PHU (CL-PHU) was prepared by heating using benzoyl peroxide as a crosslinker. According to the degree of crosslinking in the polymer, three types of CL-PHU were prepared: CL-PHU50, CL-PHU60 and CL-PHU70. Fourier transform-infrared spectroscopy, thermogravimetric analysis, and differential scanning calorimetry results suggested that crosslinking of PHU was successfully achieved by heat, which increased the crosslinking density and decreased stiffness and flexibility of the polymer. Water contact angle measurements revealed no differences of hydrophilicity as the crosslinking density. Slight morphological changes of CL-PHU film surfaces were observed by atomic force microscopy. Chinese hamster ovary cells were used to investigate the biocompatibility of CL-PHU films using poly(l-lactide) surfaces as control. Surface properties of the film, such as roughness and adhesive force, enhanced the adhesion and proliferation of cells on the films. CL-PHU might be useful for cell compatible biomedical applications.
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2017.08.170