The distribution of total vitamin B12, holotranscobalamin, and the active vitamin B12 fraction in the first 5 weeks postpartum

Introduction Total vitamin B12 levels decrease significantly during pregnancy and recover to normal values within 8‐week postpartum. Holotranscobalamin (holoTC) reflects the active part of vitamin B12 and has been shown to remain constant during pregnancy and postpartum. A mechanism of redistributio...

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Bibliographic Details
Published in:International journal of laboratory hematology 2018-02, Vol.40 (1), p.72-76
Main Authors: Woude, D. A. A., Pijnenborg, J. M. A., Vries, J., Wijk, E. M.
Format: Article
Language:English
Subjects:
Adult
cobalamin
Female
holotranscobalamin
Humans
postpartum
Postpartum Period - blood
Pregnancy
Time Factors
Vitamin B 12 - blood
Vitamin B 12 Deficiency - blood
vitamin B12
vitamin B12 fraction
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Summary:Introduction Total vitamin B12 levels decrease significantly during pregnancy and recover to normal values within 8‐week postpartum. Holotranscobalamin (holoTC) reflects the active part of vitamin B12 and has been shown to remain constant during pregnancy and postpartum. A mechanism of redistribution of vitamin B12 is suggested, with a shift toward holoTC if there is insufficient total vitamin B12 available. Our objective was to examine vitamin B12 deficiency and the active vitamin B12 fraction in postpartum women. Methods Total vitamin B12 and holoTC were measured in 171 women within 48 hours (T0) and at 5 weeks (T5) postpartum. Vitamin B12 deficiency was defined as total vitamin B12 
ISSN:1751-5521
1751-553X
DOI:10.1111/ijlh.12730