Nickel-catalyzed direct C-H trifluoroethylation of heteroarenes with trifluoroethyl iodide

A highly selective nickel-catalyzed C-H trifluoroethylation of heteroarenes was developed with the assistance of a monodentate directing group. This protocol provides efficient access to various trifluoroethyl-substituted heteroarenes, including indoles, pyrroles, furans, and thiophenes, with commer...

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Published in:Chemical communications (Cambridge, England) England), 2017-09, Vol.53 (74), p.10287-10290
Main Authors: Yan, Sheng-Yi, Zhang, Zhuo-Zhuo, Shi, Bing-Feng
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description A highly selective nickel-catalyzed C-H trifluoroethylation of heteroarenes was developed with the assistance of a monodentate directing group. This protocol provides efficient access to various trifluoroethyl-substituted heteroarenes, including indoles, pyrroles, furans, and thiophenes, with commercially available CF CH I as an alkylation reagent. This robust catalytic procedure is scalable and tolerates a broad range of functional groups. Moreover, multifluoroalkylation of indoles is also viable.
doi_str_mv 10.1039/c7cc05532c
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title Nickel-catalyzed direct C-H trifluoroethylation of heteroarenes with trifluoroethyl iodide
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