Live attenuated enterovirus vaccine (OPV) is not associated with islet autoimmunity in children with genetic susceptibility to type 1 diabetes: prospective cohort study

Aims/hypothesis Animal and human studies have implied that enterovirus infections may modulate the risk of islet autoimmunity and type 1 diabetes. We set out to assess whether serial administration of live oral poliovirus vaccine (OPV) in early life can influence the initiation of islet autoimmunity...

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Bibliographic Details
Published in:Diabetologia 2018, Vol.61 (1), p.203-209
Main Authors: Viskari, Hanna, Oikarinen, Sami, Hoppu, Sanna, Vuorinen, Tytti, Huhtala, Heini, Toppari, Jorma, Veijola, Riitta, Ilonen, Jorma, Knip, Mikael, Hyöty, Heikki
Format: Article
Language:English
Subjects:
Autoantibodies
Autoimmunity
Children
Cohort analysis
Diabetes
Diabetes mellitus
Glutamate decarboxylase
Human Physiology
Insulin
Insulinoma
Internal Medicine
Islet cells
Medicine
Medicine & Public Health
Metabolic Diseases
Mucosa
Polymerase chain reaction
Vaccines
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Summary:Aims/hypothesis Animal and human studies have implied that enterovirus infections may modulate the risk of islet autoimmunity and type 1 diabetes. We set out to assess whether serial administration of live oral poliovirus vaccine (OPV) in early life can influence the initiation of islet autoimmunity in a cohort of genetically predisposed children. Methods OPV was administered to 64 children and a further 251 children received inactivated poliovirus vaccine (IPV). The emergence of type 1 diabetes-associated autoantibodies in serum (autoantibodies to GAD, insulinoma-associated protein 2, insulin and islet cells) was monitored during prospective follow-up. Stool and serum samples were collected for enterovirus detection by RT-PCR. Results Administration of OPV increased enterovirus detected in stool samples from 11.3% to 38.9% ( p  
ISSN:0012-186X
1432-0428
DOI:10.1007/s00125-017-4410-4