Effects of dexamethasone and nimesulide on bisphosphonate-related osteonecrosis of the jaw: An experimental study

•Dexamethasone and nimesulide did not prevent the development of BRONJ.•Nimesulide reduced the number of polymorphonuclear neutrophils in the alveoli.•Dexamethasone reduces leucocytosis post-administration of zoledronic acid. To evaluate the effects of dexamethasone (DEX) and nimesulide (NIM) on Bis...

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Published in:Archives of oral biology 2017-11, Vol.83, p.317-326
Main Authors: Oliveira, Camila Carvalho de, Barros Silva, Paulo Goberlânio de, Ferreira, Antonio Ernando Carlos, Gonçalves, Romélia Pinheiro, Sousa, Fabrício Bitu de, Mota, Mário Rogério Lima, Alves, Ana Paula Negreiros Nunes
Format: Article
Language:English
Subjects:
Animals
Anti-inflammatory agents
Bisphosphonate-associated osteonecrosis of the jaw
Bisphosphonate-Associated Osteonecrosis of the Jaw - diagnostic imaging
Bisphosphonate-Associated Osteonecrosis of the Jaw - prevention & control
Bone Density Conservation Agents - toxicity
Dentistry
Dexamethasone
Dexamethasone - pharmacology
Diphosphonates - toxicity
Imidazoles - toxicity
Male
Nimesulide
Radiography, Dental, Digital
Rats
Rats, Wistar
Sulfonamides - pharmacology
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Summary:•Dexamethasone and nimesulide did not prevent the development of BRONJ.•Nimesulide reduced the number of polymorphonuclear neutrophils in the alveoli.•Dexamethasone reduces leucocytosis post-administration of zoledronic acid. To evaluate the effects of dexamethasone (DEX) and nimesulide (NIM) on Bisphosphonate-related Osteonecrosis of the Jaw (BRONJ) in rats. BRONJ was induced by zoledronic acid (ZA) infusion (0.2mg/kg) in Wistar rats (n=8), followed by extraction of the left lower first molar (BRONJ groups). Control groups (n=40) received saline (IV). For eight weeks, DEX (0.04, 0.4, 4mg/kg) or saline (SAL) were administered by gavage 24h before each infusion of ZA or saline (IV), or NIM (10.3mg/kg) was administered 24h and 12h before each infusion of ZA or saline (IV). The haematological analyses were conducted weekly. After euthanasia (day 70), the jaws were submitted to radiographic and microscopic analysis. Kidney, liver, spleen and stomach were analysed histopathologically. The BRONJ groups showed a higher radiolucent area compared with the control groups (p
ISSN:0003-9969
1879-1506
DOI:10.1016/j.archoralbio.2017.08.016