Colorectal Carcinogenesis: Role of Oxidative Stress and Antioxidants

One of the contributory causes of colon cancer is the negative effect of reactive oxygen species on DNA repair mechanisms. Currently, there is a growing support for the concept that oxidative stress may be an important etiological factor for carcinogenesis. The purpose of this review is to elucidate...

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Bibliographic Details
Published in:Anticancer research 2017-09, Vol.37 (9), p.4759-4766
Main Authors: Carini, Francesco, Mazzola, Margherita, Rappa, Francesca, Jurjus, Abdo, Geagea, Alice Gerges, Al Kattar, Sahar, Bou-Assi, Tarek, Jurjus, Rosalyn, Damiani, Provvidenza, Leone, Angelo, Tomasello, Giovanni
Format: Article
Language:English
Subjects:
Animals
Antioxidants - pharmacology
Carcinogenesis - drug effects
Carcinogenesis - pathology
Colorectal Neoplasms - pathology
Humans
Oxidative Stress - drug effects
Reactive Oxygen Species - metabolism
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Summary:One of the contributory causes of colon cancer is the negative effect of reactive oxygen species on DNA repair mechanisms. Currently, there is a growing support for the concept that oxidative stress may be an important etiological factor for carcinogenesis. The purpose of this review is to elucidate the role of oxidative stress in promoting colorectal carcinogenesis and to highlight the potential protective role of antioxidants. Several studies have documented the importance of antioxidants in countering oxidative stress and preventing colorectal carcinogenesis. However, there are conflicting data in the literature concerning its proper use in humans, since these studies did not yield definitive results and were performed mostly in vitro on cell populations, or in vivo in experimental animal models.
ISSN:0250-7005
1791-7530
DOI:10.21873/anticanres.11882