The biochemical effects of nano tamoxifen and some bioactive components in experimental breast cancer

• Published in: Biomedicine & pharmacotherapy 2017-11, Vol.95, p.571-576
• Main Authors: Ezzat, Afaf, Abdelhamid, Abdou Osman, El Awady, Mostafa K., Abd El Azeem, Amal S., Mohammed, Dina Mostafa
• Format: Article
• Language: English
• Subjects: Animals; Antioxidants - metabolism; Apoptosis; Apoptosis - drug effects; Bioactive components; Breast cancer; Deoxyguanosine - analogs & derivatives; Deoxyguanosine - metabolism; Estrogens - blood; Female; Lipid Peroxides - metabolism; Mammary Glands, Animal - drug effects; Mammary Glands, Animal - pathology; Mammary Neoplasms, Experimental - blood; Mammary Neoplasms, Experimental - drug therapy; Mammary Neoplasms, Experimental - pathology; Nanoparticles; Nanoparticles - chemistry; Rats; Rats, Sprague-Dawley; Receptor, ErbB-2 - metabolism; Tamoxifen; Tamoxifen - pharmacology; Tamoxifen - therapeutic use
• ISSN: 0753-3322; 1950-6007
• DOI: 10.1016/j.biopha.2017.08.099

[Display omitted] The effect of nano tamoxifen and some bioactive components such as yeast, isoflavone, and silymarin on the level of resistance and prevention of breast cancer progression in experimental animals is the target of this study. Thirty female Sprague-Dawley rats received a single medication dosage of 7,12-dimethylbenz[a]anthracene (DMBA) intragastrically. After fourteen days of DMBA admission, the procedure protocol started out. Finally, all the experimental results evaluated, tabulated and statistically analyzed. The results demonstrated a highly significant elevation in the 8-OHdG level in group 1 (nano yeast) and 3 (nano silymarin) while the results demonstrated a highly significant reduction in group 2 (nano tamoxifen). The apoptosis results demonstrated a significant elevation in group 3 (nano silymarin) where appeared significant reduction in group 4 (nano isoflavone). ErbB-2 results demonstrated a significant elevation in group 2 (nano tamoxifen) and a significant reduction in each of group 3 (nano silymarin) and 4 (nano isoflavone). The lipid peroxide level demonstrated an extremely significant reduction in group 4 (nano isoflavone). And a significant reduction of total antioxidant was observed in group 3 (nano silymarin) in comparison to injected animals control. This may be considered a new vision and strategy to resist breast cancer disease or prevent progression.