Blockade of Adenosine A sub(2A) Receptors Prevents Protein Phosphorylation in the Striatum Induced by Cortical Stimulation

Previous studies have shown that cortical stimulation selectively activates extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation and immediate early gene expression in striatal GABAergic enkephalinergic neurons. In the present study, we demonstrate that blockade of adenosine A sub(2A)...

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Bibliographic Details
Published in:The Journal of neuroscience 2006-10, Vol.26 (42), p.10808-10812
Main Authors: Quiroz, Cesar, Gomes, Catarina, Pak, Arlene C, Ribeiro, Joaquim A, Goldberg, Steven R, Hope, Bruce T, Ferre, Sergi
Format: Article
Language:English
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Summary:Previous studies have shown that cortical stimulation selectively activates extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation and immediate early gene expression in striatal GABAergic enkephalinergic neurons. In the present study, we demonstrate that blockade of adenosine A sub(2A) receptors with caffeine or a selective A sub(2A) receptor antagonist counteracts the striatal activation of cAMP-protein kinase A cascade (phosphorylation of the Ser sub(845) residue of the glutamate receptor 1 subunit of the AMPA receptor) and mitogen-activated protein kinase (ERK1/2 phosphorylation) induced by the in vivo stimulation of corticostriatal afferents. The results indicate that A sub(2A) receptors strongly modulate the efficacy of glutamatergic synapses on striatal enkephalinergic neurons.
ISSN:0270-6474
1529-2401