Transcription factor retention on mitotic chromosomes: regulatory mechanisms and impact on cell fate decisions

During mitosis, gene transcription stops, and the bulk of DNA‐binding proteins are excluded from condensed chromosomes. While most gene‐specific transcription factors are largely evicted from mitotic chromosomes, a subset remains bound to specific and non‐specific DNA sites. Here, we review the curr...

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Bibliographic Details
Published in:FEBS letters 2018-03, Vol.592 (6), p.878-887
Main Authors: Raccaud, Mahé, Suter, David M.
Format: Article
Language:English
Subjects:
cell fate
mitotic bookmarking
mitotic chromosomes
M‐G1 transition
non‐specific DNA binding
transcription factors
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Summary:During mitosis, gene transcription stops, and the bulk of DNA‐binding proteins are excluded from condensed chromosomes. While most gene‐specific transcription factors are largely evicted from mitotic chromosomes, a subset remains bound to specific and non‐specific DNA sites. Here, we review the current knowledge on the mechanisms leading to the retention of a subset of transcription factors on mitotic chromosomes and discuss the implications in gene expression regulation and their potential as an epigenetic mechanism controlling stem cell self‐renewal and differentiation.
ISSN:0014-5793
1873-3468
DOI:10.1002/1873-3468.12828