Genetic Design via Combinatorial Constraint Specification

We present a formal language for specifying via constraints a “design space” of DNA constructs composed of genetic parts, and an algorithm for automatically and correctly creating a novel representation of the space of satisfying designs. The language is simple, captures a large class of design spac...

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Bibliographic Details
Published in:ACS synthetic biology 2017-11, Vol.6 (11), p.2130-2135
Main Authors: Bhatia, Swapnil P, Smanski, Michael J, Voigt, Christopher A, Densmore, Douglas M
Format: Article
Language:English
Subjects:
Algorithms
DNA - genetics
Genetic Engineering - methods
Models, Genetic
Nitrogen Fixation - genetics
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Summary:We present a formal language for specifying via constraints a “design space” of DNA constructs composed of genetic parts, and an algorithm for automatically and correctly creating a novel representation of the space of satisfying designs. The language is simple, captures a large class of design spaces, and possesses algorithms for common operations on design spaces. The flexibility of this approach is demonstrated using a 16-gene nitrogen fixation pathway and genetic logic circuits.
ISSN:2161-5063
2161-5063
DOI:10.1021/acssynbio.7b00154