Oxidative Heck Reaction as a Tool for Para-selective Olefination of Aniline: A DFT Supported Mechanism

This study describes the first para-selective palladium-catalyzed alkenylation of tertiary amines. This regioselective C–H activation was conducted without any chelation moieties. A series of olefins were reacted under mild reaction conditions at 60 °C, and the corresponding products were obtained i...

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Bibliographic Details
Published in:Journal of organic chemistry 2017-10, Vol.82 (19), p.10635-10640
Main Authors: Moghaddam, Firouz Matloubi, Pourkaveh, Raheleh, Karimi, Ashkan
Format: Article
Language:English
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Summary:This study describes the first para-selective palladium-catalyzed alkenylation of tertiary amines. This regioselective C–H activation was conducted without any chelation moieties. A series of olefins were reacted under mild reaction conditions at 60 °C, and the corresponding products were obtained in good yields with high selectivity.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.7b01570