Administration of adjuvant chemotherapy in older patients with Stage III colon cancer: an observational study

Aim According to established guidelines, patients with Stage III colon cancer should receive adjuvant chemotherapy. However, a significant proportion do not. This study assessed factors associated with the administration of adjuvant chemotherapy and causes of death. Methods Patients with Stage III c...

Full description

Saved in:
Bibliographic Details
Published in:Colorectal disease 2017-10, Vol.19 (10), p.O358-O364
Main Authors: Broek, C. B. M., Puylaert, C. C. E. M., Breugom, A. J., Bastiaannet, E., Craen, A. J. M., Velde, C. J. H., Liefers, G.‐J., Portielje, J. E. A.
Format: Article
Language:English
Subjects:
adjuvant chemotherapy
Adult
Age Factors
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Cancer therapies
Cause of Death
Chemotherapy
Chemotherapy, Adjuvant - mortality
Chi-Square Distribution
Colon cancer
Colonic Neoplasms - drug therapy
Colonic Neoplasms - mortality
Colonic Neoplasms - pathology
Colorectal cancer
comorbidities
Death
elderly
Female
Humans
Life span
Male
Medical records
Middle Aged
Neoplasm Staging
Netherlands
Observational studies
Patients
Surgery
Survival
Survival Rate
The Netherlands
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aim According to established guidelines, patients with Stage III colon cancer should receive adjuvant chemotherapy. However, a significant proportion do not. This study assessed factors associated with the administration of adjuvant chemotherapy and causes of death. Methods Patients with Stage III colon cancer who underwent surgery between 2000 and 2009 were selected from two hospitals in the Netherlands. Patient characteristics including comorbidities and treatment preferences, tumour characteristics and follow‐up were extracted from the medical records. The patient and tumour characteristics of patients who did receive chemotherapy were compared with those who did not using chi‐squared analysis. Differences between the groups in causes of death were recorded together with the duration of follow‐up. Results A total of 348 patients were included. The median age was 73 years (range 33–93). Over half of the patients received adjuvant chemotherapy (50.6%). Patients who did not receive adjuvant chemotherapy were significantly older (P 
ISSN:1462-8910
1463-1318
DOI:10.1111/codi.13876