Recent advances in transition-metal-catalyzed reactions of alkynes with isoxazoles

Isoxazoles, as masked 1,3-dicarbonyl equivalents, have proven to be versatile building blocks and pivotal intermediates for the construction of a variety of useful azacycles with molecular complexity. As a result, a range of new reactions have been discovered based on isoxazoles in the past decade....

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2017-10, Vol.15 (4), p.8483-8492
Main Authors: Li, Long, Tan, Tong-De, Zhang, Ying-Qi, Liu, Xin, Ye, Long-Wu
Format: Article
Language:English
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Summary:Isoxazoles, as masked 1,3-dicarbonyl equivalents, have proven to be versatile building blocks and pivotal intermediates for the construction of a variety of useful azacycles with molecular complexity. As a result, a range of new reactions have been discovered based on isoxazoles in the past decade. However, the relevant reactions of isoxazoles with alkynes have seldom been explored. In this review, we will focus on the recent progress in the transition-metal-catalyzed formal annulations for the efficient synthesis of N-heterocycles between alkynes and isoxazoles by highlighting their specificity and applicability, and the mechanistic rationale is presented where possible. In this review, recent progress in the transition-metal-catalyzed formal annulations of alkynes with isoxazoles for the efficient synthesis of N-heterocycles is discussed.
ISSN:1477-0520
1477-0539
DOI:10.1039/c7ob01895a