Elevated serum 14-3-3η protein may be helpful for diagnosis of early rheumatoid arthritis associated with secondary osteoporosis in Chinese population

• Published in: Clinical rheumatology 2017-11, Vol.36 (11), p.2581-2587
• Main Authors: Gong, Xun, Xu, Sheng-qian, Wu, Ying, Ma, Can-chen, Qi, Shan, Liu, Wen, Xu, Jian-hua
• Format: Article
• Language: English
• Subjects: 14-3-3 Proteins - blood; Absorptiometry, Photon; Adult; Arthritis, Rheumatoid - blood; Arthritis, Rheumatoid - complications; Arthritis, Rheumatoid - diagnosis; Asian Continental Ancestry Group; Bone Density - physiology; Bone mass; Bone mineral density; Case-Control Studies; China; Correlation analysis; Cross-Sectional Studies; Diagnosis; Dual energy X-ray absorptiometry; Enzyme-linked immunosorbent assay; Female; Femur; Femur - diagnostic imaging; Humans; Inflammation; Lumbar Vertebrae - diagnostic imaging; Male; Medicine; Medicine & Public Health; Middle Aged; Original Article; Osteopenia; Osteoporosis; Osteoporosis - blood; Osteoporosis - complications; Osteoporosis - diagnostic imaging; Proteins; Rheumatoid arthritis; Rheumatology; Serum levels; Spine (lumbar)
• ISSN: 0770-3198; 1434-9949
• DOI: 10.1007/s10067-017-3807-2

Osteoporosis (OP) is one of the signs of bone damage in rheumatoid arthritis (RA). The 14-3-3η protein is an inflammatory protein, which has been reported to be associated with rheumatoid arthritis (RA). This is to determine the serum levels of 14-3-3η protein, evaluate its diagnostic value in early RA, and clear out its significance in RA with secondary osteoporosis. Two hundred fifty-nine RA patients and 80 age and sex-matched healthy controls were included. Assays of serum 14-3-3η protein were done for all participants by enzyme-linked immunosorbent assay (ELISA). Dual-energy X-ray absorptiometry (DEXA) was used to measure bone mineral density (BMD). Serum 14-3-3η protein level was significantly high in RA (2.49/4.72), compared with controls ( P