Impact of Laboratory Cross-Contamination on Molecular Epidemiology Studies of Tuberculosis

Laboratory cross-contamination by Mycobacterium tuberculosis is known to be responsible for the misdiagnosis of tuberculosis, but its impact on other contexts has not been analyzed. We present the findings of a molecular epidemiology analysis in which the recent transmission events identified by a g...

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Bibliographic Details
Published in:Journal of Clinical Microbiology 2006-08, Vol.44 (8), p.2967-2969
Main Authors: Martínez, Miguel, García de Viedma, Darío, Alonso, María, Andrés, Sandra, Bouza, Emilio, Cabezas, Teresa, Cabeza, Isabel, Reyes, Armando, Sánchez-Yebra, Waldo, Rodríguez, Manuel, Sánchez, M. Isabel, Rogado, M. Cruz, Fernández, Rosa, Peñafiel, Teresa, Martínez, Juan, Barroso, Pilar, Lucerna, M. Ángeles, Diez, L. Felipe, Gutiérrez, Carmelo
Format: Article
Language:English
Subjects:
Bacterial diseases
Bacterial Typing Techniques
Biological and medical sciences
Diagnostic Errors
Equipment Contamination
Fundamental and applied biological sciences. Psychology
Human bacterial diseases
Humans
Infectious diseases
Medical sciences
Microbiology
Molecular Epidemiology
Mycobacteriology and Aerobic Actinomycetes
Mycobacterium tuberculosis
Mycobacterium tuberculosis - classification
Tuberculosis - diagnosis
Tuberculosis - epidemiology
Tuberculosis and atypical mycobacterial infections
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Summary:Laboratory cross-contamination by Mycobacterium tuberculosis is known to be responsible for the misdiagnosis of tuberculosis, but its impact on other contexts has not been analyzed. We present the findings of a molecular epidemiology analysis in which the recent transmission events identified by a genotyping reference center were overestimated as a result of unnoticed laboratory cross-contamination in the original diagnostic laboratories.
ISSN:0095-1137
1098-660X
1098-5530
DOI:10.1128/JCM.00754-06