New Cytotoxic Triterpenoid Saponins from the Roots of Albizia gummifera (J.F.Gmel.) C.A.Sm

As part of our search for new bioactive saponins from Cameroonian medicinal plants, two new oleanane‐type saponins, named gummiferaosides D and E (1 and 2), along with one known saponin, julibroside J8 (3), were isolated from the roots of Albizia gummifera. Their structures were established on the b...

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Bibliographic Details
Published in:Chemistry & biodiversity 2017-10, Vol.14 (10), p.n/a
Main Authors: Simo, Line Made, Noté, Olivier Placide, Mbing, Joséphine Ngo, Aouazou, Sarah Ali, Guillaume, Dominique, Muller, Christian Dominique, Pegnyemb, Dieudonné Emmanuel, Lobstein, Annelise
Format: Article
Language:English
Subjects:
Albizia
Albizia gummifera
Albizzia - chemistry
Antifungal agents
Apoptosis
Apoptosis - drug effects
Apoptosis of human epidermoid cancer cell A431
Cancer
Cytotoxicity
Dose-Response Relationship, Drug
Flow cytometry
Gummiferaosides D and E
Humans
Medicinal plants
Mimosaceae
Molecular Conformation
NMR
Nuclear magnetic resonance
Plant Roots - chemistry
Plants (botany)
Roots
Samarium
Saponins
Saponins - chemistry
Saponins - isolation & purification
Saponins - pharmacology
Structure-Activity Relationship
Triterpenoid saponins
Tumor Cells, Cultured
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Summary:As part of our search for new bioactive saponins from Cameroonian medicinal plants, two new oleanane‐type saponins, named gummiferaosides D and E (1 and 2), along with one known saponin, julibroside J8 (3), were isolated from the roots of Albizia gummifera. Their structures were established on the basis of extensive 1D‐ and 2D‐NMR (1H‐ and 13C‐NMR, DEPT, COSY, TOCSY, NOESY, HSQC, HSQC‐TOCSY, and HMBC) and HR‐ESI‐MS studies, and by chemical evidence. The apoptotic effect of saponins 1 – 3 was evaluated on the A431 human epidermoid cancer cell. Flow cytometric analyses showed that saponins 1 – 3 induced apoptosis of human epidermoid cancer cell (A431) in a dose‐dependent manner.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.201700260