Analysis of acute naproxen administration on memory in young adults: A randomized, double-blind, placebo-controlled study

Nonsteroidal anti-inflammatory drugs work by non-selectively inhibiting cyclooxygenase enzymes. Evidence indicates that metabolites of the cyclooxygenase pathway play a critical role in the process of learning and memory. We evaluated whether acute naproxen treatment impairs short-term working memor...

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Bibliographic Details
Published in:Journal of psychopharmacology (Oxford) 2017-10, Vol.31 (10), p.1374-1376
Main Authors: Wilson, Jack H, Criss, Amy H, Spangler, Sean A, Walukevich, Katherine, Hewett, Sandra
Format: Article
Language:English
Subjects:
Adolescent
Adult
Adults
Amnesia
Anti-inflammatory agents
Anti-Inflammatory Agents, Non-Steroidal - administration & dosage
Anti-Inflammatory Agents, Non-Steroidal - adverse effects
Cyclooxygenase Inhibitors - administration & dosage
Cyclooxygenase Inhibitors - adverse effects
Double-Blind Method
Double-blind studies
Female
Health risk assessment
Humans
Inflammation
Learning
Male
Memory - drug effects
Mental task performance
Metabolites
Naproxen
Naproxen - administration & dosage
Naproxen - adverse effects
Prostaglandin endoperoxide synthase
Prostaglandin-Endoperoxide Synthases - metabolism
Psychopharmacology
Short term memory
Side effects
Young Adult
Young adults
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Summary:Nonsteroidal anti-inflammatory drugs work by non-selectively inhibiting cyclooxygenase enzymes. Evidence indicates that metabolites of the cyclooxygenase pathway play a critical role in the process of learning and memory. We evaluated whether acute naproxen treatment impairs short-term working memory, episodic memory, or semantic memory in a young, healthy adult population. Participants received a single dose of placebo or naproxen (750 mg) in random order separated by 7–10 days. Two hours following administration, participants completed five memory tasks. The administration of acute high-dose naproxen had no effect on memory in healthy young adults.
ISSN:0269-8811
1461-7285
DOI:10.1177/0269881117724406