Transient Splenial Lesion of the Corpus Callosum after Acute Withdrawal of Antiepileptic Drug: A Case Report

Transient lesions at the splenium of the corpus callosum (SCC) have been reported after withdrawal of specific antiepileptic drugs (AED), though the pathophysiology of the lesions remains unclear. We examined and treated a schizophrenic patient who developed a transient SCC lesion after withdrawal o...

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Bibliographic Details
Published in:Magnetic Resonance in Medical Sciences 2006, Vol.5(4), pp.211-215
Main Authors: HONDA, Kazuhiro, NISHIMIYA, Jin, SATO, Hideki, MUNAKATA, Maki, KAMADA, Masaki, IWAMURA, Akihide, NEMOTO, Hideaki, SAKAMOTO, Takashi, YUASA, Tatsuhiko
Format: Article
Language:English
Subjects:
Acute Disease
Anticonvulsants - adverse effects
Brain Diseases - chemically induced
Brain Diseases - diagnosis
carbamazepine
Carbamazepine - adverse effects
corpus callosum
Corpus Callosum - drug effects
Corpus Callosum - pathology
diabetes insipidus
diffusion-weighted image
Humans
Magnetic Resonance Imaging - methods
Male
Middle Aged
splenium
Substance Withdrawal Syndrome - diagnosis
Time Factors
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Summary:Transient lesions at the splenium of the corpus callosum (SCC) have been reported after withdrawal of specific antiepileptic drugs (AED), though the pathophysiology of the lesions remains unclear. We examined and treated a schizophrenic patient who developed a transient SCC lesion after withdrawal of the AED, carbamazepine. Interestingly, the SCC lesion was accompanied by the onset of diabetes insipidus, a state of arginine-vasopressin (AVP) insufficiency. Because carbamazepine is shown to potentiate the effect of AVP, our case suggests that an insufficiency of AVP followed by withdrawal of AED could contribute to the pathogenesis of a transient SCC lesion.
ISSN:1347-3182
1880-2206
DOI:10.2463/mrms.5.211