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Transient Splenial Lesion of the Corpus Callosum after Acute Withdrawal of Antiepileptic Drug: A Case Report

Transient lesions at the splenium of the corpus callosum (SCC) have been reported after withdrawal of specific antiepileptic drugs (AED), though the pathophysiology of the lesions remains unclear. We examined and treated a schizophrenic patient who developed a transient SCC lesion after withdrawal o...

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Published in:	Magnetic Resonance in Medical Sciences 2006, Vol.5(4), pp.211-215
Main Authors:	HONDA, Kazuhiro, NISHIMIYA, Jin, SATO, Hideki, MUNAKATA, Maki, KAMADA, Masaki, IWAMURA, Akihide, NEMOTO, Hideaki, SAKAMOTO, Takashi, YUASA, Tatsuhiko
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Language:	English
Subjects:	Acute Disease Anticonvulsants - adverse effects Brain Diseases - chemically induced Brain Diseases - diagnosis carbamazepine Carbamazepine - adverse effects corpus callosum Corpus Callosum - drug effects Corpus Callosum - pathology diabetes insipidus diffusion-weighted image Humans Magnetic Resonance Imaging - methods Male Middle Aged splenium Substance Withdrawal Syndrome - diagnosis Time Factors
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creator	HONDA, Kazuhiro NISHIMIYA, Jin SATO, Hideki MUNAKATA, Maki KAMADA, Masaki IWAMURA, Akihide NEMOTO, Hideaki SAKAMOTO, Takashi YUASA, Tatsuhiko
description	Transient lesions at the splenium of the corpus callosum (SCC) have been reported after withdrawal of specific antiepileptic drugs (AED), though the pathophysiology of the lesions remains unclear. We examined and treated a schizophrenic patient who developed a transient SCC lesion after withdrawal of the AED, carbamazepine. Interestingly, the SCC lesion was accompanied by the onset of diabetes insipidus, a state of arginine-vasopressin (AVP) insufficiency. Because carbamazepine is shown to potentiate the effect of AVP, our case suggests that an insufficiency of AVP followed by withdrawal of AED could contribute to the pathogenesis of a transient SCC lesion.
doi_str_mv	10.2463/mrms.5.211
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subjects	Acute Disease Anticonvulsants - adverse effects Brain Diseases - chemically induced Brain Diseases - diagnosis carbamazepine Carbamazepine - adverse effects corpus callosum Corpus Callosum - drug effects Corpus Callosum - pathology diabetes insipidus diffusion-weighted image Humans Magnetic Resonance Imaging - methods Male Middle Aged splenium Substance Withdrawal Syndrome - diagnosis Time Factors
title	Transient Splenial Lesion of the Corpus Callosum after Acute Withdrawal of Antiepileptic Drug: A Case Report
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