New 1,8-naphthyridine and quinoline derivatives as CB sub(2) selective agonists

A series of new 1,8-naphthyridine and quinoline derivatives were synthesized and evaluated for their cannabinoid receptor affinity. In particular, compounds 2, 5, 11, and 13 showed a high CB sub(2) affinity and CB sub(2) versus CB sub(1) selectivity, in agreement with molecular modeling studies. Fur...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry 2007-12, Vol.17 (23), p.6505-6510
Main Authors: Manera, Clementina, Cascio, Maria Grazia, Benetti, Veronica, Allara, Marco, Tuccinardi, Tiziano, Martinelli, Adriano, Saccomanni, Giuseppe, Vivoli, Elisa, Ghelardini, Carla, Di Marzo, Vincenzo, Ferrarini, Pier Luigi
Format: Article
Language:English
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Summary:A series of new 1,8-naphthyridine and quinoline derivatives were synthesized and evaluated for their cannabinoid receptor affinity. In particular, compounds 2, 5, 11, and 13 showed a high CB sub(2) affinity and CB sub(2) versus CB sub(1) selectivity, in agreement with molecular modeling studies. Furthermore, compound 2 also exhibited in vivo antinociceptive effects.
ISSN:0968-0896
1464-3391
DOI:10.1016/j.bmcl.2007.09.089