Evaluation of the changes of immune cells during lipopolysaccharide-induced mastitis in rats

The aim of this study was to evaluate in rats, changes in peripheral blood immune cells and mammary tissue after an intramammary infusion of lipopolysaccharide (LPS). The results of the study showed that infusion of LPS induced a rapid migration of neutrophils (PMNs) from the blood to mammary alveol...

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Bibliographic Details
Published in:Cytokine (Philadelphia, Pa.) Pa.), 2007-11, Vol.40 (2), p.135-143
Main Authors: Miao, Jin-Feng, Zhu, Yu-Min, Gu, Bei-Bei, Wang, Xiao-Bin, Zou, Si-Xiang, Deng, Yue-E
Format: Article
Language:English
Subjects:
Animals
CD4-CD8 Ratio
Cytokines
Female
Immune cells
Interleukin-1beta - metabolism
Interleukin-6 - metabolism
Lipopolysaccharide
Lipopolysaccharides - toxicity
Mammary Glands, Animal - metabolism
Mammary Glands, Animal - pathology
Mastitis - chemically induced
Mastitis - metabolism
Mastitis - pathology
Neutrophil Infiltration - drug effects
Neutrophils - metabolism
Neutrophils - pathology
Peroxidase - metabolism
Rat mastitis
Rats
Rats, Sprague-Dawley
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Summary:The aim of this study was to evaluate in rats, changes in peripheral blood immune cells and mammary tissue after an intramammary infusion of lipopolysaccharide (LPS). The results of the study showed that infusion of LPS induced a rapid migration of neutrophils (PMNs) from the blood to mammary alveoli, increased the activity of myeloperoxidase (MPO) and the concentration of tumor necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) in mammary tissues, decreased the activity of myeloperoxidase in serum and reduced the CD4+/CD8+ ratio. This is the first report of changes in peripheral blood immune cells and mammary tissue in rat mastitis.
ISSN:1043-4666
1096-0023
DOI:10.1016/j.cyto.2007.08.012