Central Nervous System Pathology Caused by Autoreactive CD8 super(+) T-Cell Clones following Virus Infection

Theiler's murine encephalomyelitis virus (TMEV) causes a demyelinating disease in infected mice which has similarities to multiple sclerosis. Spleen cells from TMEV-infected SJL/J mice stimulated with antigen-presenting cells infected with TMEV resulted in a population of autoreactive CD8 super...

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Bibliographic Details
Published in:Journal of virology 2005-12, Vol.79 (23), p.14640-14646
Main Authors: Tsunoda, Ikuo, Kuang, Li-Qing, Kobayashi-Warren, Mikako, Fujinami, Robert S
Format: Article
Language:English
Subjects:
Theiler's encephalomyelitis virus
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Summary:Theiler's murine encephalomyelitis virus (TMEV) causes a demyelinating disease in infected mice which has similarities to multiple sclerosis. Spleen cells from TMEV-infected SJL/J mice stimulated with antigen-presenting cells infected with TMEV resulted in a population of autoreactive CD8 super(+) cytotoxic T cells that kill uninfected syngeneic cells. We established CD8 super(+) T cell clones that could kill both TMEV-infected and uninfected syngeneic targets, although infected target cells were killed more efficiently. The CD8 super(+) T-cell clones produced gamma interferon when incubated with either infected or uninfected syngeneic target cells. Intracerebral injection of the clones into naive mice induced degeneration, not only in the brain, but also in the spinal cord. This suggests that CD8 super(+) Tc1 cells could play a pathogenic role in central nervous system inflammation.
ISSN:0022-538X
1098-5514