Identification of sialyl oligosaccharides including an oligosaccharide nucleotide in colostrum of an addax (Addax nasomaculatus) (Subfamily Antelopinae)

Mammalian milk/colostrum usually contains milk oligosaccharides along with the predominant lactose. Although milk oligosaccharides of a variety of Bovidae species including cow, sheep and goat have been characterized, those of the addax, an Antelopinae species of the Bovidae, have not as yet been cl...

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Bibliographic Details
Published in:Animal science journal 2018-01, Vol.89 (1), p.167-175
Main Authors: Ganzorig, Khuukhenbaatar, Asakawa, Takuya, Sasaki, Masashi, Saito, Tadao, Suzuki, Isao, Fukuda, Kenji, Urashima, Tadasu
Format: Article
Language:English
Subjects:
addax colostrum
Animals
Antelopes - metabolism
Bovidae milk oligosaccharides
Colostrum
Colostrum - metabolism
Lactose
Milk
milk sugar nucleotide
Nucleotides - isolation & purification
Oligosaccharides
Oligosaccharides - isolation & purification
Sheep
Sialic Acids - isolation & purification
sialyl milk oligosaccharides
Species
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Summary:Mammalian milk/colostrum usually contains milk oligosaccharides along with the predominant lactose. Although milk oligosaccharides of a variety of Bovidae species including cow, sheep and goat have been characterized, those of the addax, an Antelopinae species of the Bovidae, have not as yet been clarified. In this study, several sialyl oligosaccharides were purified from a sample of addax colostrum and characterized as follows: Neu5Ac(α2‐8)Neu5Ac(α2‐3)Gal(β1‐4)Glc, Neu5Gc(α2‐8)Neu5Gc(α2‐3)Gal(β1‐4)Glc, Neu5Ac(α2‐3)Gal(β1‐4)Glc, Neu5Ac(α2‐6)Gal(β1‐4)GlcNAc, Neu5Gc(α2‐3)Gal(β1‐4)Glc, Neu5Gc(α2‐6)Gal(β1‐4)Glc, Neu5Gc(α2‐6)Gal(β1‐4)GlcNAc. In addition, an oligosaccharide nucleotide Neu5Gc(α2‐6)Gal(β1‐4)GlcNAcα1‐UDP was characterized. Molecular species of a variety of sialyl oligosaccharides found in milk and colostrum of these Bovidae were compared.
ISSN:1344-3941
1740-0929
DOI:10.1111/asj.12899