Initial evaluation of a 99mTc-cyclopentadienyltricarbonyl technetium complex as a potential 5-HT1A receptor imaging agent

•We develop a new 99mTc-labeled for 5-HT1A receptor imaging agent.•A N-phenylferrocenecarboxamide labeled with technetium-99m (99mTc-2)has been successfully prepared in good yield.•99mTc labeled complex was able to bind specifically to rat hippocampus.•Regional brain distribution study showed a clea...

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Bibliographic Details
Published in:Applied radiation and isotopes 2017-11, Vol.129, p.196-203
Main Authors: Malek Saied, Nadia, Mejri, Najoua, Raddaoui, Mouna, Saidi, Mouldi
Format: Article
Language:English
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Summary:•We develop a new 99mTc-labeled for 5-HT1A receptor imaging agent.•A N-phenylferrocenecarboxamide labeled with technetium-99m (99mTc-2)has been successfully prepared in good yield.•99mTc labeled complex was able to bind specifically to rat hippocampus.•Regional brain distribution study showed a clear correlation between distribution of radioactivity and distribution of 5-HT1A receptors in the brain.•Blocking study confirmed that 99mTc-2 had specific binding to the 5-HT1A receptor.
ISSN:0969-8043
1872-9800
DOI:10.1016/j.apradiso.2017.08.029