Diagnostic value of 3D time-of-flight magnetic resonance angiography for detecting intracranial aneurysm: a meta-analysis

Purpose This meta-analysis is to comprehensively evaluate the diagnostic performance of three-dimensional time-of-flight magnetic resonance angiography (3D-TOF-MRA) for detecting intracranial aneurysm (IA). Methods PubMed, Embase, Web of Science, and the Cochrane library were systematically searched...

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Bibliographic Details
Published in:Neuroradiology 2017-11, Vol.59 (11), p.1083-1092
Main Authors: HaiFeng, Liu, YongSheng, Xu, YangQin, Xun, Yu, Dou, ShuaiWen, Wang, XingRu, Lu, JunQiang, Lei
Format: Article
Language:English
Subjects:
Aneurysm
Aneurysms
Angiography
Diagnosis, Differential
Diagnostic Neuroradiology
Diagnostic systems
Hemorrhage
Humans
Image processing
Image reconstruction
Imaging
Imaging, Three-Dimensional - methods
Intracranial Aneurysm - diagnostic imaging
Libraries
Likelihood ratio
Magnetic resonance
Magnetic Resonance Angiography - methods
Medical diagnosis
Medical imaging
Medicine
Medicine & Public Health
Meta-analysis
Neurology
Neuroradiology
Neurosciences
Neurosurgery
Radiology
Resonance
Sensitivity analysis
Studies
Subarachnoid hemorrhage
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Summary:Purpose This meta-analysis is to comprehensively evaluate the diagnostic performance of three-dimensional time-of-flight magnetic resonance angiography (3D-TOF-MRA) for detecting intracranial aneurysm (IA). Methods PubMed, Embase, Web of Science, and the Cochrane library were systematically searched for retrieving eligible studies. Study inclusion, data extraction, and risk of bias assessment were performed by two researchers independently. Pooled sensitivity (SEN), specificity (SPE), positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under the curve (AUC) were calculated to assess the diagnostic value. In addition, heterogeneity and subgroup analysis were carried out. Results In total, 18 studies comprising 3463 patients were selected. The results of 3D-TOF-MRA for diagnosing IA were SEN 0.89 (95% CI 0.82–0.94), SPE 0.94 (0.86–0.97), PLR 13.79 (5.92–32.12), NLR 0.11 (0.07–0.19), DOR 121.90 (38.81–382.94), and AUC 0.96 (0.94-0.98), respectively. In the subgroup analysis, studies without subarachnoid hemorrhage (SAH) tend to perform statistical significantly better ( P  
ISSN:0028-3940
1432-1920
DOI:10.1007/s00234-017-1905-0