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DNA methylation patterns at sweet taste transducing genes are associated with BMI and carbohydrate intake in an adult population
Individual differences in taste perception may influence appetite, dietary intakes, and subsequently, disease risk. Correlations of DNA methylation patterns at taste transducing genes with BMI and dietary intakes were studied. A nutriepigenomic analysis within the Methyl Epigenome Network Associatio...
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| Published in: | Appetite 2018-01, Vol.120, p.230-239 |
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| creator | Ramos-Lopez, O. Arpón, A. Riezu-Boj, J.I. Milagro, F.I. Mansego, M.L. Martinez, J.A. Abete, I. Crujeiras, A.B. Cuervo, M. Goni, L. Marti, A. Martinez-Gonzalez, M.A. Moreno-Aliaga, M.J. Navas-Carretero, S. San Cristobal, R. Santos, J.L. Zulet, M.A. |
| description | Individual differences in taste perception may influence appetite, dietary intakes, and subsequently, disease risk. Correlations of DNA methylation patterns at taste transducing genes with BMI and dietary intakes were studied. A nutriepigenomic analysis within the Methyl Epigenome Network Association (MENA) project was conducted in 474 adults. DNA methylation in peripheral white blood cells was analyzed by a microarray approach. KEGG pathway analyses were performed concerning the characterization and discrimination of genes involved in the taste transduction pathway. Adjusted FDR values (p |
| doi_str_mv | 10.1016/j.appet.2017.09.004 |
| format | article |
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Correlations of DNA methylation patterns at taste transducing genes with BMI and dietary intakes were studied. A nutriepigenomic analysis within the Methyl Epigenome Network Association (MENA) project was conducted in 474 adults. DNA methylation in peripheral white blood cells was analyzed by a microarray approach. KEGG pathway analyses were performed concerning the characterization and discrimination of genes involved in the taste transduction pathway. Adjusted FDR values (p < 0.0001) were used to select those CpGs that showed best correlation with BMI. A total of 29 CpGs at taste transducing genes met the FDR criteria. However, only 12 CpGs remained statistically significant after linear regression analyses adjusted for age and sex. These included cg15743657 (TAS1R2), cg02743674 (TRPM5), cg01790523 (SCN9A), cg15947487 (CALHM1), cg11658986 (ADCY6), cg04149773 (ADCY6), cg02841941 (P2RY1), cg02315111 (P2RX2), cg08273233 (HTR1E), cg14523238 (GABBR2), cg12315353 (GABBR1) and cg05579652 (CACNA1C). Interestingly, most of them were implicated in the sweet taste signaling pathway, except CACNA1C (sour taste). In addition, TAS1R2 methylation at cg15743657 was strongly correlated with total energy (p < 0.0001) and carbohydrate intakes (p < 0.0001). This study suggests that methylation in genes related to sweet taste could be an epigenetic mechanism associated with obesity.</description><identifier>ISSN: 0195-6663</identifier><identifier>EISSN: 1095-8304</identifier><identifier>DOI: 10.1016/j.appet.2017.09.004</identifier><identifier>PMID: 28888730</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adult ; Body Mass Index ; Dietary Carbohydrates ; Dietary intake ; DNA Methylation - genetics ; Eating - genetics ; Female ; Humans ; Linear Models ; Male ; Methylation ; Middle Aged ; Obesity ; Receptors, G-Protein-Coupled - genetics ; Signal Transduction - genetics ; Sweet taste ; TAS1R2 ; Taste perception ; Taste Perception - genetics</subject><ispartof>Appetite, 2018-01, Vol.120, p.230-239</ispartof><rights>2017 Elsevier Ltd</rights><rights>Copyright © 2017 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-df6a559afe44ec737bd710d579f03b5c7a6e8f5f40564d4064f9d1f25093a4403</citedby><cites>FETCH-LOGICAL-c359t-df6a559afe44ec737bd710d579f03b5c7a6e8f5f40564d4064f9d1f25093a4403</cites><orcidid>0000-0002-3228-9916</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28888730$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ramos-Lopez, O.</creatorcontrib><creatorcontrib>Arpón, A.</creatorcontrib><creatorcontrib>Riezu-Boj, J.I.</creatorcontrib><creatorcontrib>Milagro, F.I.</creatorcontrib><creatorcontrib>Mansego, M.L.</creatorcontrib><creatorcontrib>Martinez, J.A.</creatorcontrib><creatorcontrib>Abete, I.</creatorcontrib><creatorcontrib>Crujeiras, A.B.</creatorcontrib><creatorcontrib>Cuervo, M.</creatorcontrib><creatorcontrib>Goni, L.</creatorcontrib><creatorcontrib>Marti, A.</creatorcontrib><creatorcontrib>Martinez-Gonzalez, M.A.</creatorcontrib><creatorcontrib>Moreno-Aliaga, M.J.</creatorcontrib><creatorcontrib>Navas-Carretero, S.</creatorcontrib><creatorcontrib>San Cristobal, R.</creatorcontrib><creatorcontrib>Santos, J.L.</creatorcontrib><creatorcontrib>Zulet, M.A.</creatorcontrib><creatorcontrib>the MENA project</creatorcontrib><creatorcontrib>MENA project</creatorcontrib><title>DNA methylation patterns at sweet taste transducing genes are associated with BMI and carbohydrate intake in an adult population</title><title>Appetite</title><addtitle>Appetite</addtitle><description>Individual differences in taste perception may influence appetite, dietary intakes, and subsequently, disease risk. Correlations of DNA methylation patterns at taste transducing genes with BMI and dietary intakes were studied. A nutriepigenomic analysis within the Methyl Epigenome Network Association (MENA) project was conducted in 474 adults. DNA methylation in peripheral white blood cells was analyzed by a microarray approach. KEGG pathway analyses were performed concerning the characterization and discrimination of genes involved in the taste transduction pathway. Adjusted FDR values (p < 0.0001) were used to select those CpGs that showed best correlation with BMI. A total of 29 CpGs at taste transducing genes met the FDR criteria. However, only 12 CpGs remained statistically significant after linear regression analyses adjusted for age and sex. These included cg15743657 (TAS1R2), cg02743674 (TRPM5), cg01790523 (SCN9A), cg15947487 (CALHM1), cg11658986 (ADCY6), cg04149773 (ADCY6), cg02841941 (P2RY1), cg02315111 (P2RX2), cg08273233 (HTR1E), cg14523238 (GABBR2), cg12315353 (GABBR1) and cg05579652 (CACNA1C). Interestingly, most of them were implicated in the sweet taste signaling pathway, except CACNA1C (sour taste). In addition, TAS1R2 methylation at cg15743657 was strongly correlated with total energy (p < 0.0001) and carbohydrate intakes (p < 0.0001). 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Correlations of DNA methylation patterns at taste transducing genes with BMI and dietary intakes were studied. A nutriepigenomic analysis within the Methyl Epigenome Network Association (MENA) project was conducted in 474 adults. DNA methylation in peripheral white blood cells was analyzed by a microarray approach. KEGG pathway analyses were performed concerning the characterization and discrimination of genes involved in the taste transduction pathway. Adjusted FDR values (p < 0.0001) were used to select those CpGs that showed best correlation with BMI. A total of 29 CpGs at taste transducing genes met the FDR criteria. However, only 12 CpGs remained statistically significant after linear regression analyses adjusted for age and sex. These included cg15743657 (TAS1R2), cg02743674 (TRPM5), cg01790523 (SCN9A), cg15947487 (CALHM1), cg11658986 (ADCY6), cg04149773 (ADCY6), cg02841941 (P2RY1), cg02315111 (P2RX2), cg08273233 (HTR1E), cg14523238 (GABBR2), cg12315353 (GABBR1) and cg05579652 (CACNA1C). Interestingly, most of them were implicated in the sweet taste signaling pathway, except CACNA1C (sour taste). In addition, TAS1R2 methylation at cg15743657 was strongly correlated with total energy (p < 0.0001) and carbohydrate intakes (p < 0.0001). This study suggests that methylation in genes related to sweet taste could be an epigenetic mechanism associated with obesity.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>28888730</pmid><doi>10.1016/j.appet.2017.09.004</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-3228-9916</orcidid></addata></record> |
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| ispartof | Appetite, 2018-01, Vol.120, p.230-239 |
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| language | eng |
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| source | ScienceDirect Journals |
| subjects | Adult Body Mass Index Dietary Carbohydrates Dietary intake DNA Methylation - genetics Eating - genetics Female Humans Linear Models Male Methylation Middle Aged Obesity Receptors, G-Protein-Coupled - genetics Signal Transduction - genetics Sweet taste TAS1R2 Taste perception Taste Perception - genetics |
| title | DNA methylation patterns at sweet taste transducing genes are associated with BMI and carbohydrate intake in an adult population |
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