Gene expression and levels of IL-6 and TNFα in PBMCs correlate with severity and functional class in patients with chronic heart failure

Background Evidence shows that proinflammatory cytokines are important determinants of assessment of severity and prognosis of chronic heart failure (CHF). Aims We investigated whether peripheral expression of the proinflammmatory factors, TNF-α and IL-6 can predict variable of clinical assessment o...

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Bibliographic Details
Published in:Irish journal of medical science 2018-05, Vol.187 (2), p.359-368
Main Authors: Eskandari, V., Amirzargar, A. A., Mahmoudi, M. J., Rahnemoon, Z., Rahmani, F., Sadati, S., Rahmati, Z., Gorzin, F., Hedayat, M., Rezaei, N.
Format: Article
Language:English
Subjects:
Family Medicine
General Practice
Internal Medicine
Medicine
Medicine & Public Health
Original Article
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Summary:Background Evidence shows that proinflammatory cytokines are important determinants of assessment of severity and prognosis of chronic heart failure (CHF). Aims We investigated whether peripheral expression of the proinflammmatory factors, TNF-α and IL-6 can predict variable of clinical assessment of patients with CHF. Methods In this report, we used real-time PCR assay to compare relative gene expression of TNFα and IL-6 in PBMC from CHF patients with various heart diseases ( n  = 42, EF 
ISSN:0021-1265
1863-4362
DOI:10.1007/s11845-017-1680-2