Cartilage oligomeric matrix protein (COMP) in rheumatoid arthritis and its correlation with sonographic knee cartilage thickness and disease activity

The aim of the study is to investigate the correlation of serum cartilage oligomeric matrix protein (COMP) levels with articular cartilage damage based on sonographic knee cartilage thickness (KCT) and disease activity in rheumatoid arthritis (RA). A total of 61 RA patients and 27 healthy controls w...

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Bibliographic Details
Published in:Clinical rheumatology 2017-12, Vol.36 (12), p.2683-2688
Main Authors: Sakthiswary, Rajalingham, Rajalingam, Shamala, Hussein, Heselynn, Sridharan, Radhika, Asrul, Abdul Wahab
Format: Article
Language:English
Subjects:
Adult
Aged
Arthritis, Rheumatoid - blood
Arthritis, Rheumatoid - diagnostic imaging
Biomarkers - blood
Blood Sedimentation
C-reactive protein
C-Reactive Protein - metabolism
Cartilage (articular)
Cartilage oligomeric matrix protein
Cartilage Oligomeric Matrix Protein - blood
Cartilage, Articular - diagnostic imaging
Cross-Sectional Studies
Erythrocyte sedimentation rate
Female
Health risk assessment
Humans
Inflammation - blood
Inflammation - diagnostic imaging
Knee
Knee Joint - diagnostic imaging
Male
Matrix protein
Medicine
Medicine & Public Health
Middle Aged
Original Article
Proteins
Rheumatoid arthritis
Rheumatology
Severity of Illness Index
Ultrasonography
Ultrasound
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Summary:The aim of the study is to investigate the correlation of serum cartilage oligomeric matrix protein (COMP) levels with articular cartilage damage based on sonographic knee cartilage thickness (KCT) and disease activity in rheumatoid arthritis (RA). A total of 61 RA patients and 27 healthy controls were recruited in this study. Serum samples were obtained from all subjects to determine the serum COMP levels. All subjects had bilateral ultrasound scan of their knees. The KCT was based on the mean of measurements at three sites: the medial condyle, lateral condyle and intercondylar notch. Besides, the RA patients were assessed for their disease activity based on 28-joint-based Disease Activity Score (DAS 28). Serum COMP concentrations were significantly elevated in the RA patients compared to the controls ( p  = 0.001). The serum COMP levels had an inverse relationship with bilateral KCT in RA subjects and the healthy controls. COMP correlated significantly with disease activity based on DAS 28 ( r  = 0.299, p  = 0.010), disease duration ( r  = 0.439, p  = 
ISSN:0770-3198
1434-9949
DOI:10.1007/s10067-017-3817-0