Urolithiasis is prevalent and associated with reduced bone mineral density in β‐thalassaemia major

Asymptomatic urolithiasis is common and of mixed composition in patients with β‐thalassaemia major. Twenty‐seven subjects were imaged using dual‐energy computer tomography to determine the presence and composition of urolithiasis. The prevalence of urolithiasis was 59% and affected patients generall...

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Bibliographic Details
Published in:Internal medicine journal 2017-09, Vol.47 (9), p.1064-1067
Main Authors: Wong, Phillip, Milat, Frances, Fuller, Peter J., Kerr, Peter G., Doery, James C. G., Oh, Danielle H., Jackson, Dana, Gillespie, Matthew T., Bowden, Donald K., Pasricha, Sant‐Rayn, Lau, Ken K.
Format: Article
Language:English
Subjects:
Adult
beta-Thalassemia - diagnostic imaging
beta-Thalassemia - epidemiology
beta-Thalassemia - metabolism
Bone Density - physiology
computed tomography
Female
Humans
Hypercalcemia - diagnostic imaging
Hypercalcemia - epidemiology
Hypercalcemia - metabolism
kidney stone
Male
Middle Aged
osteoporosis
Prevalence
thalassaemia
urolithiasis
Urolithiasis - diagnostic imaging
Urolithiasis - epidemiology
Urolithiasis - metabolism
Young Adult
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Summary:Asymptomatic urolithiasis is common and of mixed composition in patients with β‐thalassaemia major. Twenty‐seven subjects were imaged using dual‐energy computer tomography to determine the presence and composition of urolithiasis. The prevalence of urolithiasis was 59% and affected patients generally had multiple stones, often with more than one component: struvite (33%), calcium oxalate (31%) and cystine (22%). Hypercalciuria was present in 78% of subjects and calcium‐containing urolithiasis was associated with reduced femoral neck Z scores.
ISSN:1444-0903
1445-5994
DOI:10.1111/imj.13533