The safety of cetirizine during pregnancy

To assess the safety of cetirizine during pregnancy. A prospective observational cohort study with data of the Berlin teratology information center from 1992 until 2006. Pregnancy outcome was compared between a cohort of pregnant women exposed to cetirizine during the first trimester ( n = 196) and...

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Bibliographic Details
Published in:Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2008-09, Vol.26 (1), p.19-23
Main Authors: Weber-Schoendorfer, Corinna, Schaefer, Christof
Format: Article
Language:English
Subjects:
Antihistamines
Birth defects
Cetirizine
Cohort study
Fetal outcome
Human
Pregnancy
Teratogenicity
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Summary:To assess the safety of cetirizine during pregnancy. A prospective observational cohort study with data of the Berlin teratology information center from 1992 until 2006. Pregnancy outcome was compared between a cohort of pregnant women exposed to cetirizine during the first trimester ( n = 196) and a control group not exposed to potential teratogens ( n = 1686). Major birth defects were not more common in the study group than in the control group (OR 1.07; CI 0.21–3.59). We also compared the crude rate of spontaneous abortions (OR 0.97; CI 0.54–1.65), of preterm deliveries (OR 0.76; CI 0.35–1.5), and the birth weight of term newborns ( p = 0.13). This prospective observational study on cetirizine in pregnancy suggests that the use of cetirizine is relatively safe during the first trimester.
ISSN:0890-6238
1873-1708
DOI:10.1016/j.reprotox.2008.05.053