Caffeine has no effect on eyeblink conditioning in mice

Caffeine is one of the most widely used drugs in the world. In the brain, caffeine acts as an antagonist for the adenosine A1 and A2B receptors. Since A1 receptors are highly concentrated in the cortex of the cerebellum, we hypothesized that caffeine could potentially affect learning tasks that requ...

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Bibliographic Details
Published in:Behavioural brain research 2018-01, Vol.337, p.252-255
Main Authors: Rasmussen, Anders, Ijpelaar, Anna C.H.G., De Zeeuw, Chris I., Boele, Henk-Jan
Format: Article
Language:English
Subjects:
Adenosine
Animals
Caffeine
Caffeine - pharmacology
Central Nervous System Stimulants - pharmacology
Cerebellum
Conditioning, Eyelid - drug effects
Dose-Response Relationship, Drug
Eyeblink conditioning
Injections, Intraperitoneal
Mice
Mice, Inbred C57BL
Motor Learning
Physical Stimulation
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Summary:Caffeine is one of the most widely used drugs in the world. In the brain, caffeine acts as an antagonist for the adenosine A1 and A2B receptors. Since A1 receptors are highly concentrated in the cortex of the cerebellum, we hypothesized that caffeine could potentially affect learning tasks that require the cerebellar cortex, such as eyeblink conditioning. To test this hypothesis, we examined the effect of low (5mg/kg) and high (50mg/kg) doses of caffeine, injected intraperitoneally before training, on eyeblink conditioning in mice. The results show that, at the dosages we used, caffeine affects neither the rate of acquisition, nor the timing of the onset or peak of the conditioned blink responses. Therefore, we conclude that caffeine neither improves nor worsens performance on eyeblink conditioning.
ISSN:0166-4328
1872-7549
DOI:10.1016/j.bbr.2017.09.013