Cisplatin-Induced Toxicity Is Associated with Platinum Deposition in Mouse Kidney Mitochondria in Vivo and with Selective Inactivation of the alpha -Ketoglutarate Dehydrogenase Complex in LLC-PK sub(1) Cells

The anticancer drug cisplatin is nephrotoxic and neurotoxic. Previous data support the hypothesis that cisplatin is bioactivated to a nephrotoxicant. The final step in the proposed bioactivation is the formation of a platinum-cysteine S-

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Bibliographic Details
Published in:Biochemistry (Easton) 2006-07, Vol.45 (29), p.8959-8971
Main Authors: Zhang, L, Cooper, AJL, Krasnikov, B F, Xu, H, Bubber, P, Pinto, J T, Gibson, GE, Hanigan, M H
Format: Article
Language:English
Online Access:Get full text
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Summary:The anticancer drug cisplatin is nephrotoxic and neurotoxic. Previous data support the hypothesis that cisplatin is bioactivated to a nephrotoxicant. The final step in the proposed bioactivation is the formation of a platinum-cysteine S-
ISSN:0006-2960
DOI:10.1021/bi060027g