Toxic Effects of Brominated Indoles and Phenols on Zebrafish Embryos

Organobromine compounds in the marine environment have been the focus of growing attention in past years. In contrast to anthropogenic brominated flame retardants, other brominated compounds are produced naturally, e.g., by common polychaete worms and algae. Brominated phenols and indoles assumed to...

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Bibliographic Details
Published in:Archives of environmental contamination and toxicology 2006-07, Vol.51 (1), p.97-102
Main Authors: Kammann, U, Vobach, M, Wosniok, W
Format: Article
Language:English
Subjects:
Agnatha. Pisces
Algae
Animal, plant and microbial ecology
Animals
Anthropogenic factors
Applied ecology
Biological and medical sciences
Danio rerio
Ecotoxicology, biological effects of pollution
Embryonic Development - drug effects
Embryos
Fish
Flame retardants
Freshwater
Fundamental and applied biological sciences. Psychology
General aspects
Indoles
Indoles - toxicity
Lethal Dose 50
Marine
Marine environment
Marine fish
Mode of action
Phenols
Phenols - toxicity
Pigmentation - drug effects
Quantitative Structure-Activity Relationship
Spine - drug effects
Spine - embryology
Vertebrates: general zoology, morphology, phylogeny, systematics, cytogenetics, geographical distribution
Water analysis
Water sampling
Yolk Sac - drug effects
Zebrafish
Zebrafish - embryology
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Summary:Organobromine compounds in the marine environment have been the focus of growing attention in past years. In contrast to anthropogenic brominated flame retardants, other brominated compounds are produced naturally, e.g., by common polychaete worms and algae. Brominated phenols and indoles assumed to be of biogenic origin have been detected in water and sediment extracts from the German Bight. These substances as well as some of their isomers have been tested with the zebrafish embryo test and were found to cause lethal as well as nonlethal malformations. The zebrafish test was able to detect a log K(OW)-related toxicity for bromophenols, suggesting nonpolar narcosis as a major mode of action. Different effect patterns could be observed for brominated indoles and bromophenols. The comparison of effective concentrations in the zebrafish embryo test with the concentrations determined in water samples suggests the possibility that brominated indoles may affect early life stages of marine fish species in the North Sea.
ISSN:0090-4341
1432-0703
DOI:10.1007/s00244-005-0152-2