Factors associated with HIV prevalence in a pre-partum cohort of Zambian women

An ongoing study of mother-to-child human herpes virus-8 (HHV-8) transmission in Zambian women (n = 3160) allowed us to examine the association of medical injections with HIV serostatus while simultaneously accounting for other factors known to be correlated with HIV prevalence. Multi-method data co...

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Bibliographic Details
Published in:International journal of STD & AIDS 2006-09, Vol.17 (9), p.607-613
Main Authors: LAWRENCE, J. S. St, KLASKALA, W, KANKASA, C, WEST, J. T, MITCHELL, C. D, WOOD, C
Format: Article
Language:English
Subjects:
Alcohol Drinking
Biological and medical sciences
Cohort Studies
Data Collection
Epidemiology. Vaccinations
Female
General aspects
HIV Infections - epidemiology
HIV Infections - transmission
HIV Seropositivity
Human herpesvirus 8
Human immunodeficiency virus
Human viral diseases
Humans
Infectious diseases
Injections, Intramuscular
Injections, Intravenous
Logistic Models
Medical sciences
Pregnancy
Prevalence
Risk Factors
Sexual Behavior
Sexually Transmitted Diseases
Substance-Related Disorders
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Zambia - epidemiology
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Summary:An ongoing study of mother-to-child human herpes virus-8 (HHV-8) transmission in Zambian women (n = 3160) allowed us to examine the association of medical injections with HIV serostatus while simultaneously accounting for other factors known to be correlated with HIV prevalence. Multi-method data collection included structured interviews, medical record abstraction, clinical examinations, and biological measures. Medically administered intramuscular or intravenous injections in the past five years (but not blood transfusions) were overwhelmingly correlated with HIV prevalence, exceeding the contribution of sexual behaviours in a multivariable logistic regression. Statistically significant associations with HIV also were found for some demographic variables, sexual behaviours, alcohol use, and sexually transmitted diseases (STD). The results confirmed that iatrogenic needle exposure, sexual behaviour, demographic factors, substance use, and STD history are all implicated in Zambian women's HIV+ status. However, the disproportionate association of medical injection history with HIV highlights the need to investigate further and prospectively the role of health-care injection in sub-Saharan Africa's HIV epidemic.
ISSN:0956-4624
1758-1052
DOI:10.1258/095646206778113050