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Analysis of serum levels and cutaneous expression of lipoprotein (a) in 38 patients with livedoid vasculopathy
Background Coagulation disorders contribute to the development of livedoid vasculopathy (LV). Elevated plasma levels of lipoprotein(a) [Lp(a)] are an independent risk factor for the development of cardiovascular disease and associated with hypercoagulable states. Increased serum Lp(a) levels have be...
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| Published in: | Journal of cutaneous pathology 2017-12, Vol.44 (12), p.1033-1037 |
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| cites | cdi_FETCH-LOGICAL-c3533-abec2c6cc2f90dcda44999c86dc220d8f9224488899dd0660adc4e43775fe0ce3 |
| container_end_page | 1037 |
| container_issue | 12 |
| container_start_page | 1033 |
| container_title | Journal of cutaneous pathology |
| container_volume | 44 |
| creator | Espinel, Danielle P.G.S. Di Giacomo, Thais B. Pincelli, Thais P. Pereira, Naiura V. Sotto, Miriam N. Kirsner, Robert S. Criado, Paulo R. |
| description | Background
Coagulation disorders contribute to the development of livedoid vasculopathy (LV). Elevated plasma levels of lipoprotein(a) [Lp(a)] are an independent risk factor for the development of cardiovascular disease and associated with hypercoagulable states. Increased serum Lp(a) levels have been reported in patients with LV and may have an important role in the pathogenesis of LV.
Objectives
To investigate Lp(a) expression in skin lesions and circulating serum Lp(a) levels in patients with LV.
Methods
Skin biopsy samples from 38 patients (27 women and 11 men) with active lesions diagnosed as LV and 9 samples of normal skin (5 women and 4 men) from control patients without LV were evaluated for skin expression of Lp(a) by immunohistochemistry. Plasma levels of Lp(a) were analyzed by immunoturbidimetry.
Results
We found that lesional skin in patients with LV expressed 10‐fold higher Lp(a) immunostaining than controls. High plasma levels of Lp(a) were observed in LV patients. We did not find a correlation (P = .02) between expression of Lp(a) in the skin and plasma levels of Lp(a) in patients with LV.
Conclusions
Increased Lp(a) expression in lesional skin of LV patients suggests the role of Lp(a) in the thrombo‐occlusive vasculopathy observed in this disease. |
| doi_str_mv | 10.1111/cup.13043 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1938604310</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1938604310</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3533-abec2c6cc2f90dcda44999c86dc220d8f9224488899dd0660adc4e43775fe0ce3</originalsourceid><addsrcrecordid>eNp10U9P2zAYBnBrGhoFdtgXmCztAofA69hx7WNV8U-qBAc4R679RjVy4yxOyvrt5xK2AxK-vAf_9Mh-H0J-MLhk-VzZsbtkHAT_QmZMAhRQSfhKZsCBF1Kr-TE5SekFgEklq2_kuFQaWCX5jLSL1oR98onGhibsxy0NuMOQqGkdteNgWoxjovin6zElH9sDDL6LXR8H9C09Nxc0D65oZwaP7ZDoqx822ezQRe_oziQ7hphvN_szctSYkPD7-zwlzzfXT8u7YvVwe79crArLK84Ls0ZbWmlt2Whw1hkhtNZWSWfLEpxqdFkKoZTS2jmQEoyzAgWfz6sGwSI_JedTbn7l7xHTUG99shjC9J2aaa5kXhiDTH99oC9x7PNWDkpKzUAokdXFpGwfU-qxqbveb02_rxnUhxLqXEL9VkK2P98Tx_UW3X_5b-sZXE3g1Qfcf55UL58fp8i_iHqRdw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1966910484</pqid></control><display><type>article</type><title>Analysis of serum levels and cutaneous expression of lipoprotein (a) in 38 patients with livedoid vasculopathy</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Espinel, Danielle P.G.S. ; Di Giacomo, Thais B. ; Pincelli, Thais P. ; Pereira, Naiura V. ; Sotto, Miriam N. ; Kirsner, Robert S. ; Criado, Paulo R.</creator><creatorcontrib>Espinel, Danielle P.G.S. ; Di Giacomo, Thais B. ; Pincelli, Thais P. ; Pereira, Naiura V. ; Sotto, Miriam N. ; Kirsner, Robert S. ; Criado, Paulo R.</creatorcontrib><description>Background
Coagulation disorders contribute to the development of livedoid vasculopathy (LV). Elevated plasma levels of lipoprotein(a) [Lp(a)] are an independent risk factor for the development of cardiovascular disease and associated with hypercoagulable states. Increased serum Lp(a) levels have been reported in patients with LV and may have an important role in the pathogenesis of LV.
Objectives
To investigate Lp(a) expression in skin lesions and circulating serum Lp(a) levels in patients with LV.
Methods
Skin biopsy samples from 38 patients (27 women and 11 men) with active lesions diagnosed as LV and 9 samples of normal skin (5 women and 4 men) from control patients without LV were evaluated for skin expression of Lp(a) by immunohistochemistry. Plasma levels of Lp(a) were analyzed by immunoturbidimetry.
Results
We found that lesional skin in patients with LV expressed 10‐fold higher Lp(a) immunostaining than controls. High plasma levels of Lp(a) were observed in LV patients. We did not find a correlation (P = .02) between expression of Lp(a) in the skin and plasma levels of Lp(a) in patients with LV.
Conclusions
Increased Lp(a) expression in lesional skin of LV patients suggests the role of Lp(a) in the thrombo‐occlusive vasculopathy observed in this disease.</description><identifier>ISSN: 0303-6987</identifier><identifier>EISSN: 1600-0560</identifier><identifier>DOI: 10.1111/cup.13043</identifier><identifier>PMID: 28901563</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Biopsy ; Female ; Humans ; Immunohistochemistry ; Leg Ulcer - complications ; Leg Ulcer - pathology ; leg ulcers ; lipoprotein (a) ; Lipoprotein(a) - blood ; Lipoprotein(a) - metabolism ; Livedo Reticularis - blood ; Livedo Reticularis - complications ; Livedo Reticularis - metabolism ; Livedo Reticularis - pathology ; livedoid vasculopathy ; Male ; Middle Aged ; Plasma ; Plasma levels ; Serum levels ; Skin - metabolism ; Skin - pathology ; Skin diseases ; Skin Diseases - metabolism ; Skin Diseases - pathology ; thrombophilia ; Thrombophilia - metabolism ; Thrombophilia - physiopathology ; thrombosis ; Vascular Diseases ; Young Adult</subject><ispartof>Journal of cutaneous pathology, 2017-12, Vol.44 (12), p.1033-1037</ispartof><rights>2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3533-abec2c6cc2f90dcda44999c86dc220d8f9224488899dd0660adc4e43775fe0ce3</citedby><cites>FETCH-LOGICAL-c3533-abec2c6cc2f90dcda44999c86dc220d8f9224488899dd0660adc4e43775fe0ce3</cites><orcidid>0000-0001-9785-6099 ; 0000-0001-9020-109X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28901563$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Espinel, Danielle P.G.S.</creatorcontrib><creatorcontrib>Di Giacomo, Thais B.</creatorcontrib><creatorcontrib>Pincelli, Thais P.</creatorcontrib><creatorcontrib>Pereira, Naiura V.</creatorcontrib><creatorcontrib>Sotto, Miriam N.</creatorcontrib><creatorcontrib>Kirsner, Robert S.</creatorcontrib><creatorcontrib>Criado, Paulo R.</creatorcontrib><title>Analysis of serum levels and cutaneous expression of lipoprotein (a) in 38 patients with livedoid vasculopathy</title><title>Journal of cutaneous pathology</title><addtitle>J Cutan Pathol</addtitle><description>Background
Coagulation disorders contribute to the development of livedoid vasculopathy (LV). Elevated plasma levels of lipoprotein(a) [Lp(a)] are an independent risk factor for the development of cardiovascular disease and associated with hypercoagulable states. Increased serum Lp(a) levels have been reported in patients with LV and may have an important role in the pathogenesis of LV.
Objectives
To investigate Lp(a) expression in skin lesions and circulating serum Lp(a) levels in patients with LV.
Methods
Skin biopsy samples from 38 patients (27 women and 11 men) with active lesions diagnosed as LV and 9 samples of normal skin (5 women and 4 men) from control patients without LV were evaluated for skin expression of Lp(a) by immunohistochemistry. Plasma levels of Lp(a) were analyzed by immunoturbidimetry.
Results
We found that lesional skin in patients with LV expressed 10‐fold higher Lp(a) immunostaining than controls. High plasma levels of Lp(a) were observed in LV patients. We did not find a correlation (P = .02) between expression of Lp(a) in the skin and plasma levels of Lp(a) in patients with LV.
Conclusions
Increased Lp(a) expression in lesional skin of LV patients suggests the role of Lp(a) in the thrombo‐occlusive vasculopathy observed in this disease.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biopsy</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Leg Ulcer - complications</subject><subject>Leg Ulcer - pathology</subject><subject>leg ulcers</subject><subject>lipoprotein (a)</subject><subject>Lipoprotein(a) - blood</subject><subject>Lipoprotein(a) - metabolism</subject><subject>Livedo Reticularis - blood</subject><subject>Livedo Reticularis - complications</subject><subject>Livedo Reticularis - metabolism</subject><subject>Livedo Reticularis - pathology</subject><subject>livedoid vasculopathy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Plasma</subject><subject>Plasma levels</subject><subject>Serum levels</subject><subject>Skin - metabolism</subject><subject>Skin - pathology</subject><subject>Skin diseases</subject><subject>Skin Diseases - metabolism</subject><subject>Skin Diseases - pathology</subject><subject>thrombophilia</subject><subject>Thrombophilia - metabolism</subject><subject>Thrombophilia - physiopathology</subject><subject>thrombosis</subject><subject>Vascular Diseases</subject><subject>Young Adult</subject><issn>0303-6987</issn><issn>1600-0560</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp10U9P2zAYBnBrGhoFdtgXmCztAofA69hx7WNV8U-qBAc4R679RjVy4yxOyvrt5xK2AxK-vAf_9Mh-H0J-MLhk-VzZsbtkHAT_QmZMAhRQSfhKZsCBF1Kr-TE5SekFgEklq2_kuFQaWCX5jLSL1oR98onGhibsxy0NuMOQqGkdteNgWoxjovin6zElH9sDDL6LXR8H9C09Nxc0D65oZwaP7ZDoqx822ezQRe_oziQ7hphvN_szctSYkPD7-zwlzzfXT8u7YvVwe79crArLK84Ls0ZbWmlt2Whw1hkhtNZWSWfLEpxqdFkKoZTS2jmQEoyzAgWfz6sGwSI_JedTbn7l7xHTUG99shjC9J2aaa5kXhiDTH99oC9x7PNWDkpKzUAokdXFpGwfU-qxqbveb02_rxnUhxLqXEL9VkK2P98Tx_UW3X_5b-sZXE3g1Qfcf55UL58fp8i_iHqRdw</recordid><startdate>201712</startdate><enddate>201712</enddate><creator>Espinel, Danielle P.G.S.</creator><creator>Di Giacomo, Thais B.</creator><creator>Pincelli, Thais P.</creator><creator>Pereira, Naiura V.</creator><creator>Sotto, Miriam N.</creator><creator>Kirsner, Robert S.</creator><creator>Criado, Paulo R.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9785-6099</orcidid><orcidid>https://orcid.org/0000-0001-9020-109X</orcidid></search><sort><creationdate>201712</creationdate><title>Analysis of serum levels and cutaneous expression of lipoprotein (a) in 38 patients with livedoid vasculopathy</title><author>Espinel, Danielle P.G.S. ; Di Giacomo, Thais B. ; Pincelli, Thais P. ; Pereira, Naiura V. ; Sotto, Miriam N. ; Kirsner, Robert S. ; Criado, Paulo R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3533-abec2c6cc2f90dcda44999c86dc220d8f9224488899dd0660adc4e43775fe0ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biopsy</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Leg Ulcer - complications</topic><topic>Leg Ulcer - pathology</topic><topic>leg ulcers</topic><topic>lipoprotein (a)</topic><topic>Lipoprotein(a) - blood</topic><topic>Lipoprotein(a) - metabolism</topic><topic>Livedo Reticularis - blood</topic><topic>Livedo Reticularis - complications</topic><topic>Livedo Reticularis - metabolism</topic><topic>Livedo Reticularis - pathology</topic><topic>livedoid vasculopathy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Plasma</topic><topic>Plasma levels</topic><topic>Serum levels</topic><topic>Skin - metabolism</topic><topic>Skin - pathology</topic><topic>Skin diseases</topic><topic>Skin Diseases - metabolism</topic><topic>Skin Diseases - pathology</topic><topic>thrombophilia</topic><topic>Thrombophilia - metabolism</topic><topic>Thrombophilia - physiopathology</topic><topic>thrombosis</topic><topic>Vascular Diseases</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Espinel, Danielle P.G.S.</creatorcontrib><creatorcontrib>Di Giacomo, Thais B.</creatorcontrib><creatorcontrib>Pincelli, Thais P.</creatorcontrib><creatorcontrib>Pereira, Naiura V.</creatorcontrib><creatorcontrib>Sotto, Miriam N.</creatorcontrib><creatorcontrib>Kirsner, Robert S.</creatorcontrib><creatorcontrib>Criado, Paulo R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cutaneous pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Espinel, Danielle P.G.S.</au><au>Di Giacomo, Thais B.</au><au>Pincelli, Thais P.</au><au>Pereira, Naiura V.</au><au>Sotto, Miriam N.</au><au>Kirsner, Robert S.</au><au>Criado, Paulo R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of serum levels and cutaneous expression of lipoprotein (a) in 38 patients with livedoid vasculopathy</atitle><jtitle>Journal of cutaneous pathology</jtitle><addtitle>J Cutan Pathol</addtitle><date>2017-12</date><risdate>2017</risdate><volume>44</volume><issue>12</issue><spage>1033</spage><epage>1037</epage><pages>1033-1037</pages><issn>0303-6987</issn><eissn>1600-0560</eissn><abstract>Background
Coagulation disorders contribute to the development of livedoid vasculopathy (LV). Elevated plasma levels of lipoprotein(a) [Lp(a)] are an independent risk factor for the development of cardiovascular disease and associated with hypercoagulable states. Increased serum Lp(a) levels have been reported in patients with LV and may have an important role in the pathogenesis of LV.
Objectives
To investigate Lp(a) expression in skin lesions and circulating serum Lp(a) levels in patients with LV.
Methods
Skin biopsy samples from 38 patients (27 women and 11 men) with active lesions diagnosed as LV and 9 samples of normal skin (5 women and 4 men) from control patients without LV were evaluated for skin expression of Lp(a) by immunohistochemistry. Plasma levels of Lp(a) were analyzed by immunoturbidimetry.
Results
We found that lesional skin in patients with LV expressed 10‐fold higher Lp(a) immunostaining than controls. High plasma levels of Lp(a) were observed in LV patients. We did not find a correlation (P = .02) between expression of Lp(a) in the skin and plasma levels of Lp(a) in patients with LV.
Conclusions
Increased Lp(a) expression in lesional skin of LV patients suggests the role of Lp(a) in the thrombo‐occlusive vasculopathy observed in this disease.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>28901563</pmid><doi>10.1111/cup.13043</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0001-9785-6099</orcidid><orcidid>https://orcid.org/0000-0001-9020-109X</orcidid></addata></record> |
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| ispartof | Journal of cutaneous pathology, 2017-12, Vol.44 (12), p.1033-1037 |
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| language | eng |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Adolescent Adult Biopsy Female Humans Immunohistochemistry Leg Ulcer - complications Leg Ulcer - pathology leg ulcers lipoprotein (a) Lipoprotein(a) - blood Lipoprotein(a) - metabolism Livedo Reticularis - blood Livedo Reticularis - complications Livedo Reticularis - metabolism Livedo Reticularis - pathology livedoid vasculopathy Male Middle Aged Plasma Plasma levels Serum levels Skin - metabolism Skin - pathology Skin diseases Skin Diseases - metabolism Skin Diseases - pathology thrombophilia Thrombophilia - metabolism Thrombophilia - physiopathology thrombosis Vascular Diseases Young Adult |
| title | Analysis of serum levels and cutaneous expression of lipoprotein (a) in 38 patients with livedoid vasculopathy |
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