Microcytosis is associated with low cognitive outcomes in healthy 2-year-olds in a high-resource setting

Fe deficiency in early childhood is associated with long-term consequences for cognitive, motor and behavioural development; however explorations in healthy children from low risk, high-resource settings have been limited. We aimed to explore associations between Fe status and neurodevelopmental out...

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Bibliographic Details
Published in:British journal of nutrition 2017-09, Vol.118 (5), p.360-367
Main Authors: McCarthy, Elaine K., Kiely, Mairead E., Hannon, Geraldine, Ahearne, Caroline, Kenny, Louise C., Hourihane, Jonathan O’B., Irvine, Alan D., Murray, Deirdre M.
Format: Article
Language:English
Subjects:
Age
Anemia
Anemia, Iron-Deficiency
Babies
Balances (scales)
Birth weight
Case-Control Studies
Child Development
Child, Preschool
Children
Children & youth
Cognition - physiology
Cognitive ability
Cognitive development
Cognitive Dysfunction - blood
Cognitive Dysfunction - complications
Communication
Cork
Criteria
Diagnostic systems
Endpoint Determination
Erythrocyte Indices
Female
Ferritin
Ferritins - blood
Health risk assessment
Hemoglobins - metabolism
Hospitals
Human and Clinical Nutrition
Humans
Infants
Iron
Iron - blood
Iron - deficiency
Laboratories
Longitudinal Studies
Male
Medical screening
Neurodevelopment
Nutrition research
Pregnancy
Prospective Studies
Secondary analysis
Socioeconomic factors
University colleges
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Summary:Fe deficiency in early childhood is associated with long-term consequences for cognitive, motor and behavioural development; however explorations in healthy children from low risk, high-resource settings have been limited. We aimed to explore associations between Fe status and neurodevelopmental outcomes in low risk, healthy 2-year-olds. This study was a secondary analysis of a nested case–control subgroup from the prospective, maternal-infant Cork Babies after Screening for Pregnancy Endpoints: Evaluating the Longitudinal Impact using Neurological and Nutritional Endpoints (BASELINE) Birth Cohort Study. At 2 years, serum ferritin, Hb and mean corpuscular volume (MCV) were measured and neurodevelopment was assessed using the Bayley Scales of Infant and Toddler Development (n 87). Five children had Fe deficiency (ferritin
ISSN:0007-1145
1475-2662
DOI:10.1017/S0007114517001945